Dr. Alex C. Ko Profile

Dr. Alex C. Ko

Research Officer at Natl Research Council Canada

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Author

Publications (15)

Proceedings Article | 29 August 2017 Paper

Fibre-optic laser Raman sensor for chlorinated hydrocarbons in water by integration of solid phase microextraction waveguide media

Alex C.-T. Ko

Proceedings Volume 10313, 103132C (2017) https://doi.org/10.1117/12.2283880

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Proceedings Article | 19 April 2017 Presentation

Ex-vivo evaluation of an early caries detector based on integrated OCT and polarized Raman spectroscopy (Conference Presentation)

Guy Lamouche, Christian Padioleau, Mark Hewko, Michael S. Smith, Bernie Schattka, Crystal Fulton, Bruno Gauthier, André Beauchesne, Alex Ko, Lin-P'ing Choo-Smith, Michael Sowa

Proceedings Volume 10044, 1004405 (2017) https://doi.org/10.1117/12.2253224

KEYWORDS: Dental caries, Raman spectroscopy, Optical coherence tomography, Sensors, Teeth, Space reconnaissance, Microelectromechanical systems, Image processing, Laser dentistry, Spectroscopes

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SPIE Journal Paper | 18 April 2016 Open Access

Review of near-infrared methods for wound assessment

Michael Sowa, Wen-Chuan Kuo, Alex Ko, David Armstrong

JBO, Vol. 21, Issue 09, 091304, (April 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.9.091304

KEYWORDS: Wound healing, Tissues, Collagen, Tissue optics, Speckle, Blood, Near infrared, Optical coherence tomography, Light scattering, Scattering

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Proceedings Article | 28 February 2014 Paper

Evaluating collagen morphology and pathological lipid deposition using multiphoton image statistics

Leila Mostaço-Guidolin, Alex C.-T. Ko, Fei Wang, Hong Tian, Mark Hewko, Masashi Shiomi, Arkady Major, Michael Sowa

Proceedings Volume 8948, 89482A (2014) https://doi.org/10.1117/12.2038232

KEYWORDS: Collagen, Second-harmonic generation, Tissues, Image classification, Particles, Image analysis, Microscopy, Arteries, Microscopes, Statistical analysis

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Proceedings Article | 23 February 2011 Paper

Using multimodal femtosecond CARS imaging to determine plaque burden in luminal atherosclerosis

Alex C-T. Ko, Leila Mostaço-Guidolin, Andrew Ridsdale, Adrian Pegoraro, Michael S. Smith, Aaron Slepkov, Mark Hewko, Elicia Kohlenberg, Bernie Schattka, Albert Stolow, Michael Sowa

Proceedings Volume 7903, 790318 (2011) https://doi.org/10.1117/12.873867

KEYWORDS: Second-harmonic generation, Collagen, Femtosecond phenomena, CARS tomography, Arteries, Tissues, Image analysis, Microscopes, Microscopy, Statistical analysis

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SPIE Journal Paper | 1 March 2010 Open Access

Multimodal nonlinear optical imaging of atherosclerotic plaque development in myocardial infarction-prone rabbits

Alex Ko, Andrew Ridsdale, Michael Smith, Leila Mostaço-Guidolin, Mark Hewko, Adrian Pegoraro, Elicia Kohlenberg, Bernhard Schattka, Masashi Shiomi, Albert Stolow, Michael Sowa

JBO, Vol. 15, Issue 02, 020501, (March 2010) https://doi.org/10.1117/12.10.1117/1.3353960

KEYWORDS: Collagen, Microscopes, Femtosecond phenomena, Nonlinear optics, Tissues, CARS tomography, Objectives, Multimodal imaging, Optical imaging, Tissue optics

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Proceedings Article | 5 August 2009 Paper

A single-photon fluorescence and multi-photon spectroscopic study of atherosclerotic lesions

Michael S. D. Smith, Alex C. T. Ko, Andrew Ridsdale, Bernie Schattka, Adrian Pegoraro, Mark Hewko, Masashi Shiomi, Albert Stolow, Michael Sowa

Proceedings Volume 7386, 73860I (2009) https://doi.org/10.1117/12.840500

KEYWORDS: Luminescence, Tissues, Second-harmonic generation, Spectroscopy, Tissue optics, Microscopes, Single photon, Mirrors, Fluorescence spectroscopy, Multiphoton spectroscopy

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Proceedings Article | 24 February 2009 Paper

Label-free imaging of arterial tissues using photonic crystal fiber (PCF) based nonlinear optical microscopic system

Alex C. Ko, Andrew Ridsdale, Adrian Pegoraro, Michael S. Smith, Leila Mostaço-Guidolin, Mark Hewko, Elicia Kohlenberg, Bernie Schattka, Masashi Shiomi, Albert Stolow, Michael Sowa

Proceedings Volume 7182, 718204 (2009) https://doi.org/10.1117/12.809361

KEYWORDS: Tissues, Imaging systems, Collagen, Microscopes, Nonlinear optics, Photonic crystal fibers, Natural surfaces, Second-harmonic generation, Objectives, Complex systems

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Proceedings Article | 23 March 2007 Paper

Broadband coherent anti-Stokes Raman scattering (CARS): a potential tool for atherosclerosis diagnostic imaging

J.-F. Cormier, A. Ko, L.-P. Choo-Smith, J. Werner, E. Kohlenberg, M. Hewko, J. Fréchette, M. Fortin, I. Noiseux, J. P. Bouchard, David Gay, P. Desroches, Francois Roy-Moisan, Marie-Eve Bourgault, M. Sowa, M. Vernon

Proceedings Volume 6424, 64241X (2007) https://doi.org/10.1117/12.701243

KEYWORDS: Raman spectroscopy, Control systems, Tissues, CARS tomography, Arteries, Spectroscopy, Collagen, Luminescence, Principal component analysis, Molecules

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Proceedings Article | 8 September 2006 Paper

Dental caries detection by optical spectroscopy: a polarized Raman approach with fibre-optic coupling

A. C.-T. Ko, L.-P. Choo-Smith, J. Werner, M. Hewko, M. Sowa, C. Dong, B. Cleghorn

Proceedings Volume 6343, 634303 (2006) https://doi.org/10.1117/12.706544

KEYWORDS: Raman spectroscopy, Dental caries, Teeth, Polarization, Anisotropy, Fiber couplers, Spectroscopy, Microscopes, Objectives, Photomicroscopy

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Proceedings Article | 27 February 2006 Paper

Application of NIR Raman spectroscopy for detecting and characterizing early dental caries

A. Ko, L.-P. Choo-Smith, R. Zhu, M. Hewko, C. Dong, B. Cleghorn, M. Sowa

Proceedings Volume 6093, 60930L (2006) https://doi.org/10.1117/12.647159

KEYWORDS: Raman spectroscopy, Dental caries, Teeth, Polarization, Anisotropy, Near infrared, Lawrencium, Data modeling, Photomicroscopy, Spectroscopy

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Proceedings Article | 22 February 2006 Paper

Atherosclerosis diagnostic imaging by optical spectroscopy and optical coherence tomography

M. D. Hewko, L. P. Choo-Smith, A. C. T. Ko, M. S. D. Smith, E. M. Kohlenberg, E. R. Bock, L. Leonardi, M. G. Sowa

Proceedings Volume 6078, 60782E (2006) https://doi.org/10.1117/12.641438

KEYWORDS: Raman spectroscopy, Collagen, Arteries, Optical coherence tomography, Tissues, Near infrared, Diagnostics, Luminescence, Imaging spectroscopy, Optical imaging

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Atherosclerosis is traditionally viewed as a disease of uncontrolled plaque growth leading to arterial occlusion. More recently, however, occlusion of the arterial lumen is being viewed as an acute event triggered by plaque rupture and thrombosis. An atheromatous plaque becomes vulnerable to sudden activation and/or rupture when a constellation of processes are activated by various trigger mechanisms. There is growing evidence that the vulnerability (i.e. susceptibility to rupture) and thrombogenic nature of the plaque need to be taken into account in the planning and treatment of the disease. X-ray fluoroscopy and intravascular ultrasound, the current clinical diagnostic tools are not capable of the providing a complete histological picture of the plaque region. Intravascular diagnostic imaging of coronary atherosclerotic plaques by optical means to assess plaque, patient risk and assist in planning treatment strategies represents the future in angioplasty treatment by interventional cardiologists. The techniques which will enable a clinically acceptable and reliable intravascular diagnostic platform are currently being investigated and compared to the clinical standard of histology. Currently, we are investigating the use of a number of optical and imaging techniques for biochemical analysis of arterial tissue including Raman, near infrared and fluorescence spectroscopies. Biochemical imaging will provide compositional information on collagen, elastin, lipid and thrombogenic by-products as well as gauging inflammation and tissue remodeling activity levels. To complement the functional biochemical imaging, optical coherence tomography will be provide structural morphological imaging. The synergistic combination of functional and structural imagery will provide the interventional cardiologist with a complete clinical picture of the atherosclerotic plaque region. The clinician can use this diagnostic information to plan a personalized treatment procedure based on the entire clinical presentation.

Proceedings Article | 15 February 2006 Paper

Characterization of early dental caries by polarized Raman spectroscopy

Lin-P'ing Choo-Smith, Alex C.-T. Ko, Mark Hewko, Cecilia C. S. Dong, Blaine Cleghorn, Michael Sowa

Proceedings Volume 6137, 613706 (2006) https://doi.org/10.1117/12.646795

KEYWORDS: Raman spectroscopy, Teeth, Dental caries, Polarization, Linear polarizers, Dentistry, Apatite, Crystals, Near infrared, Microscopes

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SPIE Journal Paper | 1 May 2005 Open Access

Ex vivo detection and characterization of early dental caries by optical coherence tomography and Raman spectroscopy

Alex Ko, Lin-P'ing Choo-Smith, Mark Hewko, Lorenzo Leonardi, Michael Sowa, Cecilia Dong, Peter Williams, Blaine Cleghorn

JBO, Vol. 10, Issue 03, 031118, (May 2005) https://doi.org/10.1117/12.10.1117/1.1915488

KEYWORDS: Raman spectroscopy, Teeth, Dental caries, Optical coherence tomography, Fiber optics, Crystals, Luminescence, Imaging spectroscopy, Polarization, Spectroscopy

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Proceedings Article | 23 March 2005 Paper

OCT of early dental caries: a comparative study with histology and Raman spectroscopy

Mark Hewko, Lin-P'ing Choo-Smith, Alex Ko, Lorenzo Leonardi, Cecilia Dong, Blaine Cleghorn, Michael Sowa

Proceedings Volume 5687, (2005) https://doi.org/10.1117/12.590955

KEYWORDS: Optical coherence tomography, Teeth, Dental caries, Raman spectroscopy, Minerals, Imaging systems, Visualization, Imaging spectroscopy, Visible radiation, Bacteria

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Showing 5 of 15 publications

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