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1 October 2003 Optical imaging of metastatic tumors using a folate-targeted fluorescent probe
Michael D. Kennedy, Karim N. Jallad, David H. Thompson, Dor Ben-Amotz, Philip S. Low
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Journal of Biomedical Optics, Vol. 8, Issue 4, (October 2003). https://doi.org/10.1117/1.1609453
We describe the use of a tumor targeting ligand, the vitamin folic acid, to deliver an attached fluorescent probe to both primary and metastatic tumors overexpressing the folate receptor. Upon laser excitation, derived images of normal tissues generally show little or no fluorescence, whereas images of folate receptor-expressing tumors display bright fluorescence that can be easily distinguished from adjacent normal tissue. Furthermore, metastatic tumor loci of submillimeter size can also be visualized without the aid of image processing or enhancement. The sharp distinction between tumor and normal tissues provided by this technique could find application in the localization and resection of tumor tissue during surgery or in the enhanced endoscopic detection and staging of cancers.
©(2003) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Michael D. Kennedy, Karim N. Jallad, David H. Thompson, Dor Ben-Amotz, and Philip S. Low "Optical imaging of metastatic tumors using a folate-targeted fluorescent probe," Journal of Biomedical Optics 8(4), (1 October 2003). https://doi.org/10.1117/1.1609453
Published: 1 October 2003
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Cited by 81 scholarly publications and 10 patents.
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KEYWORDS
Tumors
Tissues
Luminescence
Receptors
Optical imaging
Cancer
Surgery
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