Assessment of an in situ temporal calibration method for time-resolved optical tomography

Jeremy C. Hebden; Felipe Gonzalez; Adam Gibson; Elizabeth M. C. Hillman; Rozarina Md Yusof; Nick Everdell; David T. Delpy; Giovanni Zaccanti; Fabrizio Martelli

doi:10.1117/1.1528206

1 January 2003 Assessment of in situ temporal calibration method for time-resolved optical tomography

Jeremy C. Hebden, Felipe Gonzalez, Adam Gibson, Elizabeth M. C. Hillman, Rozarina Md Yusof, Nick Everdell, David T. Delpy, Giovanni Zaccanti, Fabrizio Martelli

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Journal of Biomedical Optics, Vol. 8, Issue 1, (January 2003). https://doi.org/10.1117/1.1528206

A 32-channel time-resolved optical imaging device is developed at University College London to produce functional images of the neonatal brain and the female breast. Reconstruction of images using time-resolved measurements of transmitted light requires careful calibration of the temporal characteristics of the measurement system. Since they can often vary over a period of time, it is desirable to evaluate these characteristics immediately after, or prior to, the acquisition of image data. A calibration technique is investigated that is based on the measurement of light back-reflected from the surface of the object being imaged. This is facilitated by coupling each detector channel with an individual source fiber. A Monte Carlo model is employed to investigate the influence of the optical properties of the object on the back-reflected signal. The results of simulations indicate that their influence may be small enough to be ignored in some cases, or could be largely accounted for by a small adjustment to the calibrated data. The effectiveness of the method is briefly demonstrated by imaging a solid object with tissue-equivalent optical properties.

©(2003) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Jeremy C. Hebden, Felipe Gonzalez, Adam Gibson, Elizabeth M. C. Hillman, Rozarina Md Yusof, Nick Everdell, David T. Delpy, Giovanni Zaccanti, and Fabrizio Martelli "Assessment of in situ temporal calibration method for time-resolved optical tomography," Journal of Biomedical Optics 8(1), (1 January 2003). https://doi.org/10.1117/1.1528206

Published: 1 January 2003

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