Nonscanning large-area Raman imaging for ex vivo/in vivo skin cancer discrimination

Elmar Schmälzlin; Benito Moralejo; Ingo Gersonde; Johannes Schleusener; Maxim E. Darvin; Gisela Thiede; Martin M. Roth

doi:10.1117/1.JBO.23.10.105001

4 October 2018 Nonscanning large-area Raman imaging for ex vivo / in vivo skin cancer discrimination

Elmar Schmälzlin, Benito Moralejo, Ingo Gersonde, Johannes Schleusener, Maxim E. Darvin, Gisela Thiede, Martin M. Roth

Author Affiliations +

Journal of Biomedical Optics, Vol. 23, Issue 10, 105001 (October 2018). https://doi.org/10.1117/1.JBO.23.10.105001

Abstract

Imaging Raman spectroscopy can be used to identify cancerous tissue. Traditionally, a step-by-step scanning of the sample is applied to generate a Raman image, which, however, is too slow for routine examination of patients. By transferring the technique of integral field spectroscopy (IFS) from astronomy to Raman imaging, it becomes possible to record entire Raman images quickly within a single exposure, without the need for a tedious scanning procedure. An IFS-based Raman imaging setup is presented, which is capable of measuring skin ex vivo or in vivo. It is demonstrated how Raman images of healthy and cancerous skin biopsies were recorded and analyzed.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

Elmar Schmälzlin, Benito Moralejo, Ingo Gersonde, Johannes Schleusener, Maxim E. Darvin, Gisela Thiede, and Martin M. Roth "Nonscanning large-area Raman imaging for ex vivo / in vivo skin cancer discrimination," Journal of Biomedical Optics 23(10), 105001 (4 October 2018). https://doi.org/10.1117/1.JBO.23.10.105001

Received: 1 June 2018; Accepted: 31 August 2018; Published: 4 October 2018

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
11 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 16 scholarly publications.

Explore citations on Lens.org

KEYWORDS

Raman spectroscopy

Skin

In vivo imaging

Skin cancer

Head

Tissues

Biopsy

Show All Keywords

RELATED CONTENT

Development of a fiber based Raman probe compatible with interventional...
Proceedings of SPIE (February 27 2014)

Development and characterization of a disposable sub millimeter fiberoptic Raman...
Proceedings of SPIE (January 01 1900)

Label-free multispectral lifetime fluorescence to distinguish skin lesions
Proceedings of SPIE (March 04 2019)

Comparison of Raman spectroscopy equipment for tissues and biofluids analysis
Proceedings of SPIE (April 27 2016)

Fluorescence ratiometric classifier for the detection of skin pathologies
Proceedings of SPIE (July 15 2015)

Evaluation of variations of biomolecular constituents in human skin in...
Proceedings of SPIE (October 25 2001)

<i>In vivo < i> analysis of tissue by Raman microprobe...
Proceedings of SPIE (February 27 2006)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years