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22 September 2016 Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography
Behrooz Zabihian, Zhe Chen, Elisabet Rank, Christoph Sinz, Marco Bonesi, Harald Sattmann, Jason R. Ensher, Michael P. Minneman, Erich E. Hoover, Jessika Weingast, Laurin Ginner, Rainer A. Leitgeb, Harald Kittler, Edward Z. Zhang, Paul C. Beard, Wolfgang Drexler, Mengyang Liu
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Journal of Biomedical Optics, Vol. 21, Issue 9, 096011 (September 2016). https://doi.org/10.1117/1.JBO.21.9.096011
Abstract
Studies have proven the relationship between cutaneous vasculature abnormalities and dermatological disorders, but to image vasculature noninvasively in vivo, advanced optical imaging techniques are required. In this study, we imaged a palm of a healthy volunteer and three subjects with cutaneous abnormalities with photoacoustic tomography (PAT) and optical coherence tomography with angiography extension (OCTA). Capillaries in the papillary dermis that are too small to be discerned with PAT are visualized with OCTA. From our results, we speculate that the PA signal from the palm is mostly from hemoglobin in capillaries rather than melanin, knowing that melanin concentration in volar skin is significantly smaller than that in other areas of the skin. We present for the first time OCTA images of capillaries along with the PAT images of the deeper vessels, demonstrating the complementary effective imaging depth range and the visualization capabilities of PAT and OCTA for imaging human skin in vivo. The proposed imaging system in this study could significantly improve treatment monitoring of dermatological diseases associated with cutaneous vasculature abnormalities.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Behrooz Zabihian, Zhe Chen, Elisabet Rank, Christoph Sinz, Marco Bonesi, Harald Sattmann, Jason R. Ensher, Michael P. Minneman, Erich E. Hoover, Jessika Weingast, Laurin Ginner, Rainer A. Leitgeb, Harald Kittler, Edward Z. Zhang, Paul C. Beard, Wolfgang Drexler, and Mengyang Liu "Comprehensive vascular imaging using optical coherence tomography-based angiography and photoacoustic tomography," Journal of Biomedical Optics 21(9), 096011 (22 September 2016). https://doi.org/10.1117/1.JBO.21.9.096011
Published: 22 September 2016
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Cited by 16 scholarly publications.
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KEYWORDS
Acquisition tracking and pointing
Capillaries
Skin
Optical coherence tomography
Visualization
Angiography
Imaging systems
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