Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery

Antonello Enrico Spinelli; Marco Paolo Schiariti; Chiara Maria Grana; Mahila Ferrari; Marta Cremonesi; Federico Boschi

doi:10.1117/1.JBO.21.5.050502

9 May 2016 Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery

Antonello Enrico Spinelli, Marco Paolo Schiariti, Chiara Maria Grana, Mahila Ferrari, Marta Cremonesi, Federico Boschi

Author Affiliations +

Journal of Biomedical Optics, Vol. 21, Issue 5, 050502 (May 2016). https://doi.org/10.1117/1.JBO.21.5.050502

Abstract

We presented the first example of Cerenkov luminescence imaging (CLI) and radioluminescence imaging (RLI) of human tumor specimens. A patient with a brain meningioma localized in the left parietal region was injected with 166 MBq of ⁹⁰Y-DOTATOC the day before neurosurgery. The specimens of the tumor removed during surgery were imaged using both CLI and RLI using an optical imager prototype developed in our laboratory. The system is based on a cooled electron multiplied charge coupled device coupled with an f/0.95 17-mm C-mount lens. We showed for the first time the possibility of obtaining CLI and RLI images of fresh human brain tumor specimens removed during neurosurgery.

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Antonello Enrico Spinelli, Marco Paolo Schiariti, Chiara Maria Grana, Mahila Ferrari, Marta Cremonesi, and Federico Boschi "Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery," Journal of Biomedical Optics 21(5), 050502 (9 May 2016). https://doi.org/10.1117/1.JBO.21.5.050502

Published: 9 May 2016

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KEYWORDS

Tumors

Brain

Surgery

Neuroimaging

Cerenkov radiation imaging

Charge-coupled devices

Luminescence

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