CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 21 > Issue 3 > Article
Open Access
8 March 2016 Optical tweezers study of red blood cell aggregation and disaggregation in plasma and protein solutions
Kisung Lee, Matti Kinnunen, Maria D. Khokhlova, Evgeny V. Lyubin, Alexander V. Priezzhev, Igor Meglinski, Andrey A. Fedyanin
Author Affiliations +
Funded by: Academy of Finland, Russian Foundation
Journal of Biomedical Optics, Vol. 21, Issue 3, 035001 (March 2016). https://doi.org/10.1117/1.JBO.21.3.035001
Abstract
Kinetics of optical tweezers (OT)-induced spontaneous aggregation and disaggregation of red blood cells (RBCs) were studied at the level of cell doublets to assess RBC interaction mechanics. Measurements were performed under in vitro conditions in plasma and fibrinogen and fibrinogen + albumin solutions. The RBC spontaneous aggregation kinetics was found to exhibit different behavior depending on the cell environment. In contrast, the RBC disaggregation kinetics was similar in all solutions qualitatively and quantitatively, demonstrating a significant contribution of the studied proteins to the process. The impact of the study on assessing RBC interaction mechanics and the protein contribution to the reversible RBC aggregation process is discussed.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Citation Download Citation
Kisung Lee, Matti Kinnunen, Maria D. Khokhlova, Evgeny V. Lyubin, Alexander V. Priezzhev, Igor Meglinski, and Andrey A. Fedyanin "Optical tweezers study of red blood cell aggregation and disaggregation in plasma and protein solutions," Journal of Biomedical Optics 21(3), 035001 (8 March 2016). https://doi.org/10.1117/1.JBO.21.3.035001
Published: 8 March 2016
JOURNAL ARTICLE
 10 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 71 scholarly publications.
Advertisement
Advertisement
KEYWORDS
Plasma
Proteins
Blood
Optical tweezers
Magnesium
Macromolecules
Mechanics
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top