Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol

Heidrun Wabnitz; Alexander Jelzow; Mikhail Mazurenka; Oliver Steinkellner; Rainer Macdonald; Daniel Milej; Norbert Żołek; Michał Kacprzak; Piotr Sawosz; Roman Maniewski; Adam Liebert; Salavat Magazov; Jeremy C. Hebden; Fabrizio Martelli; Paola Di Ninni; Giovanni Zaccanti; Alessandro Torricelli; Davide Contini; Rebecca Re; Lucia M. Zucchelli; Lorenzo Spinelli; Rinaldo Cubeddu; Antonio Pifferi

doi:10.1117/1.JBO.19.8.086012

14 August 2014 Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol

Heidrun Wabnitz, Alexander Jelzow, Mikhail Mazurenka, Oliver Steinkellner, Rainer Macdonald, Daniel Milej, Norbert Żołek, Michał Kacprzak, Piotr Sawosz, Roman Maniewski, Adam Liebert, Salavat Magazov, Jeremy C. Hebden, Fabrizio Martelli, Paola Di Ninni, Giovanni Zaccanti, Alessandro Torricelli, Davide Contini, Rebecca Re, Lucia M. Zucchelli, Lorenzo Spinelli, Rinaldo Cubeddu, Antonio Pifferi

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Journal of Biomedical Optics, Vol. 19, Issue 8, 086012 (August 2014). https://doi.org/10.1117/1.JBO.19.8.086012

Abstract

The nEUROPt protocol is one of two new protocols developed within the European project nEUROPt to characterize the performances of time-domain systems for optical imaging of the brain. It was applied in joint measurement campaigns to compare the various instruments and to assess the impact of technical improvements. This protocol addresses the characteristic of optical brain imaging to detect, localize, and quantify absorption changes in the brain. It was implemented with two types of inhomogeneous liquid phantoms based on Intralipid and India ink with well-defined optical properties. First, small black inclusions were used to mimic localized changes of the absorption coefficient. The position of the inclusions was varied in depth and lateral direction to investigate contrast and spatial resolution. Second, two-layered liquid phantoms with variable absorption coefficients were employed to study the quantification of layer-wide changes and, in particular, to determine depth selectivity, i.e., the ratio of sensitivities for deep and superficial absorption changes. We introduce the tests of the nEUROPt protocol and present examples of results obtained with different instruments and methods of data analysis. This protocol could be a useful step toward performance tests for future standards in diffuse optical imaging.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Heidrun Wabnitz, Alexander Jelzow, Mikhail Mazurenka, Oliver Steinkellner, Rainer Macdonald, Daniel Milej, Norbert Żołek, Michał Kacprzak, Piotr Sawosz, Roman Maniewski, Adam Liebert, Salavat Magazov, Jeremy C. Hebden, Fabrizio Martelli, Paola Di Ninni, Giovanni Zaccanti, Alessandro Torricelli, Davide Contini, Rebecca Re, Lucia M. Zucchelli, Lorenzo Spinelli, Rinaldo Cubeddu, and Antonio Pifferi "Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol," Journal of Biomedical Optics 19(8), 086012 (14 August 2014). https://doi.org/10.1117/1.JBO.19.8.086012

Published: 14 August 2014

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