Spatial frequency analysis of high-density lipoprotein and iron-oxide nanoparticle transmission electron microscope image structure for pattern recognition in heterogeneous fields

Stewart Russell; Thien An Nguyen; Clyde Rey Torres; Stephen Bhagroo; Milo J. Russell; Robert R. Alfano

doi:10.1117/1.JBO.19.1.015004

3 January 2014 Spatial frequency analysis of high-density lipoprotein and iron-oxide nanoparticle transmission electron microscope image structure for pattern recognition in heterogeneous fields

Stewart Russell, Thien An Nguyen, Clyde Rey Torres, Stephen Bhagroo, Milo J. Russell, Robert R. Alfano

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Journal of Biomedical Optics, Vol. 19, Issue 1, 015004 (January 2014). https://doi.org/10.1117/1.JBO.19.1.015004

Abstract

The optical spatial frequencies of tumor interstitial fluid (TIF) are investigated. As a concentrated colloidal suspension of interacting native nanoparticles, the TIF can develop internal ordering under shear stress that may hinder delivery of antitumor agents within tumors. A systematic method is presented to characterize the TIF nanometer-scale microstructure in a model suspension of superparamagnetic iron-oxide nanoparticles and reconstituted high-density lipoprotein by Fourier spatial frequency (FSF) analysis so as to differentiate between jammed and fluid structural features in static transmission electron microscope images. The FSF method addresses one obstacle faced in achieving quantitative dosimetry to neoplastic tissue, that of detecting these nanoscale barriers to transport, such as would occur in the extravascular space immediately surrounding target cells.

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Stewart Russell, Thien An Nguyen, Clyde Rey Torres, Stephen Bhagroo, Milo J. Russell, and Robert R. Alfano "Spatial frequency analysis of high-density lipoprotein and iron-oxide nanoparticle transmission electron microscope image structure for pattern recognition in heterogeneous fields," Journal of Biomedical Optics 19(1), 015004 (3 January 2014). https://doi.org/10.1117/1.JBO.19.1.015004

Published: 3 January 2014

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