Optical imaging of acute epileptic networks in mice

Edgar Guevara; Philippe Pouliot; Dang Nguyen; Frédéric Lesage

doi:10.1117/1.JBO.18.7.076021

25 July 2013 Optical imaging of acute epileptic networks in mice

Edgar Guevara, Philippe Pouliot, Dang Nguyen, Frédéric Lesage

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Journal of Biomedical Optics, Vol. 18, Issue 7, 076021 (July 2013). https://doi.org/10.1117/1.JBO.18.7.076021

Abstract

The potential of intrinsic optical imaging and resting-state analysis under anesthetized conditions as a tool to study brain networks associated with epileptic seizures is investigated. Using an acute model of epileptiform activity, the 4-aminopyridine model in live mice, we observe the changes in resting-state networks with the onset of seizure activity and in conditions of spiking activity. Resting-state networks identified before and after the onset of epileptiform activity show both decreased and increased homologous correlations, with a small dependence on seizure intensity. The observed changes are not uniform across the different hemodynamic measures, suggesting a potential decoupling between blood flow and metabolism in the low-frequency networks. This study supports the need for a more extensive investigation of epileptic networks including more than one independent hemodynamic measurement.

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Edgar Guevara, Philippe Pouliot, Dang Nguyen, and Frédéric Lesage "Optical imaging of acute epileptic networks in mice," Journal of Biomedical Optics 18(7), 076021 (25 July 2013). https://doi.org/10.1117/1.JBO.18.7.076021

Published: 25 July 2013

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