Imaging of pharmacokinetic rates of indocyanine green in mouse liver with a hybrid fluorescence molecular tomography/x-ray computed tomography system

Guanglei Zhang; Fei Liu; Bin Zhang; Yun He; Jianwen Luo; Jing Bai

doi:10.1117/1.JBO.18.4.040505

17 April 2013 Imaging of pharmacokinetic rates of indocyanine green in mouse liver with a hybrid fluorescence molecular tomography/x-ray computed tomography system

Guanglei Zhang, Fei Liu, Bin Zhang, Yun He, Jianwen Luo, Jing Bai

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Journal of Biomedical Optics, Vol. 18, Issue 4, 040505 (April 2013). https://doi.org/10.1117/1.JBO.18.4.040505

Abstract

Pharmacokinetic rates have the potential to provide quantitative physiological and pathological information for biological studies and drug development. Fluorescence molecular tomography (FMT) is an attractive imaging tool for three-dimensionally resolving fluorophore distribution in small animals. In this letter, pharmacokinetic rates of indocyanine green (ICG) in mouse liver are imaged with a hybrid FMT and x-ray computed tomography (XCT) system. A recently developed FMT method using structural priors from an XCT system is adopted to improve the quality of FMT reconstruction. In the in vivo experiments, images of uptake and excretion rates of ICG in mouse liver are obtained, which can be used to quantitatively evaluate liver function. The accuracy of the results is validated by a fiber-based fluorescence measurement system.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Guanglei Zhang, Fei Liu, Bin Zhang, Yun He, Jianwen Luo, and Jing Bai "Imaging of pharmacokinetic rates of indocyanine green in mouse liver with a hybrid fluorescence molecular tomography/x-ray computed tomography system," Journal of Biomedical Optics 18(4), 040505 (17 April 2013). https://doi.org/10.1117/1.JBO.18.4.040505

Published: 17 April 2013

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