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3 April 2012 Photoacoustic/ultrasound dual-modality contrast agent and its application to thermotherapy
Yu-Hsin Wang, Pai-Chi Li, Ai-Ho Liao, Jui-Hao Chen, Churng-Ren Wang
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Funded by: National Science Council of Taiwan
Journal of Biomedical Optics, Vol. 17, Issue 4, 045001 (April 2012). https://doi.org/10.1117/1.JBO.17.4.045001
Abstract
This study investigates a photoacoustic/ultrasound dual-modality contrast agent, including extending its applications from image-contrast enhancement to combined diagnosis and therapy with site-specific targeting. The contrast agent comprises albumin-shelled microbubbles with encapsulated gold nanorods (AuMBs). The gas-filled microbubbles, whose diameters range from submicrometer to several micrometers, are not only echogenic but also can serve as drug-delivery vehicles. The gold nanorods are used to enhance the generation of both photoacoustic and photothermal signals. The optical absorption peak of the gold nanorods is tuned to 760 nm and is invariant after microbubble encapsulation. Dual-modality contrast enhancement is first described here, and the applications to cellular targeting and laser-induced thermotherapy in a phantom are demonstrated. Photoacoustic imaging can be used to monitor temperature increases during the treatment. The targeting capability of AuMBs was verified, and the temperature increased by 26°C for a laser power of 980 mW, demonstrating the potential of combined diagnosis and therapy with the dual-modality agent. Targeted photo- or acoustic-mediated delivery is also possible.
© 2012 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2012/$25.00 © 2012 SPIE
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Yu-Hsin Wang, Pai-Chi Li, Ai-Ho Liao, Jui-Hao Chen, and Churng-Ren Wang "Photoacoustic/ultrasound dual-modality contrast agent and its application to thermotherapy," Journal of Biomedical Optics 17(4), 045001 (3 April 2012). https://doi.org/10.1117/1.JBO.17.4.045001
Published: 3 April 2012
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Cited by 61 scholarly publications and 2 patents.
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KEYWORDS
Absorption
Temperature metrology
Nanorods
Gold
Heat therapy
Acoustics
Thermography
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