Motion-gated acquisition for in vivo optical imaging

Sylvain Gioux; Ashitate Yoshitomo M.D.; Merlijn Hutteman; John V. Frangioni M.D.

doi:10.1117/1.3275473

1 November 2009 Motion-gated acquisition for in vivo optical imaging

Sylvain Gioux, Ashitate Yoshitomo M.D., Merlijn Hutteman, John V. Frangioni M.D.

Author Affiliations +

Journal of Biomedical Optics, Vol. 14, Issue 6, 064038 (November 2009). https://doi.org/10.1117/1.3275473

Abstract

Wide-field continuous wave fluorescence imaging, fluorescence lifetime imaging, frequency domain photon migration, and spatially modulated imaging have the potential to provide quantitative measurements in vivo. However, most of these techniques have not yet been successfully translated to the clinic due to challenging environmental constraints. In many circumstances, cardiac and respiratory motion greatly impair image quality and/or quantitative processing. To address this fundamental problem, we have developed a low-cost, field-programmable gate array-based, hardware-only gating device that delivers a phase-locked acquisition window of arbitrary delay and width that is derived from an unlimited number of pseudo-periodic and nonperiodic input signals. All device features can be controlled manually or via USB serial commands. The working range of the device spans the extremes of mouse electrocardiogram (1000 beats per minute) to human respiration (4 breaths per minute), with timing resolution ≤0.06%, and jitter ≤0.008%, of the input signal period. We demonstrate the performance of the gating device, including dramatic improvements in quantitative measurements, in vitro using a motion simulator and in vivo using near-infrared fluorescence angiography of beating pig heart. This gating device should help to enable the clinical translation of promising new optical imaging technologies.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Sylvain Gioux, Ashitate Yoshitomo M.D., Merlijn Hutteman, and John V. Frangioni M.D. "Motion-gated acquisition for in vivo optical imaging," Journal of Biomedical Optics 14(6), 064038 (1 November 2009). https://doi.org/10.1117/1.3275473

Published: 1 November 2009

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Cited by 17 scholarly publications and 4 patents.

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KEYWORDS

Luminescence

Near infrared

In vivo imaging

Optical imaging

Cameras

Signal detection

Image acquisition

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