Photoacoustic tomography of small animal brain with a curved array transducer

Xinmai Yang; Anastasios Maurudis; John K. Gamelin; Andres Aguirre; Quing Zhu; Lihong V. Wang

doi:10.1117/1.3227035

1 September 2009 Photoacoustic tomography of small animal brain with a curved array transducer

Xinmai Yang, Anastasios Maurudis, John K. Gamelin, Andres Aguirre, Quing Zhu, Lihong V. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 14, Issue 5, 054007 (September 2009). https://doi.org/10.1117/1.3227035

Abstract

We present the application of a curved array photoacoustic tomographic imaging system that can provide rapid, high-resolution photoacoustic imaging of small animal brains. The system is optimized to produce a B-mode, 90-deg field-of-view image at sub-200-μm resolution at a frame rate of ~1 frame/second when a 10-Hz pulse repetition rate laser is employed. By rotating samples, a complete 360-deg scan can be achieved within 15 s. In previous work, two-dimensional (2-D) ex vivo mouse brain cortex imaging has been reported. We report three-dimensional (3-D) small animal brain imaging obtained with the curved array system. The results are presented as a series of 2-D cross-sectional images. Besides structural imaging, the blood oxygen saturation of the animal brain cortex is also measured in vivo. In addition, the system can measure the time-resolved relative changes in blood oxygen saturation level in the small animal brain cortex. Last, ultrasonic gel coupling, instead of the previously adopted water coupling, is conveniently used in near-real-time 2-D imaging.

©(2009) Society of Photo-Optical Instrumentation Engineers (SPIE)

Citation Download Citation

Xinmai Yang, Anastasios Maurudis, John K. Gamelin, Andres Aguirre, Quing Zhu, and Lihong V. Wang "Photoacoustic tomography of small animal brain with a curved array transducer," Journal of Biomedical Optics 14(5), 054007 (1 September 2009). https://doi.org/10.1117/1.3227035

Published: 1 September 2009

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
5 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

CITATIONS

Cited by 30 scholarly publications and 2 patents.

Explore citations on Lens.org

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Brain

Neuroimaging

Transducers

Acquisition tracking and pointing

Imaging systems

In vivo imaging

Photoacoustic tomography

Show All Keywords

RELATED CONTENT

Mouse brain imaging using photoacoustic computed tomography
Proceedings of SPIE (March 03 2014)

Mapping of acupuncture effects on cortex by photoacoustic tomography
Proceedings of SPIE (March 27 2022)

In vivo evaluation of cerebral venous sinus morphology using pulsed...
Proceedings of SPIE (February 17 2020)

Hybrid ultrasound and dual-wavelength optoacoustic biomicroscopy for functional neuroimaging
Proceedings of SPIE (March 03 2017)

Three dimensional photoacoustic tomography of small animal brain with a...
Proceedings of SPIE (February 12 2009)

In vivo mouse brain tomography by fast dual scanning photoacoustic...
Proceedings of SPIE (March 06 2009)

Subscribe to Digital Library

Receive Erratum Email Alert

Show All Keywords

Keywords/Phrases

Search In:

Publication Years