Analysis of the fluorescence temporal point-spread function in a turbid medium and its application to optical imaging

Sung-Ho Han; Salman Farshchi-Heydari; David J. Hall

doi:10.1117/1.3042271

1 November 2008 Analysis of the fluorescence temporal point-spread function in a turbid medium and its application to optical imaging

Sung-Ho Han, Salman Farshchi-Heydari, David J. Hall

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Journal of Biomedical Optics, Vol. 13, Issue 6, 064038 (November 2008). https://doi.org/10.1117/1.3042271

Abstract

A time-domain optical method to evaluate the concentration (n), lifetime (τ), and depth (d) of a fluorescent inclusion is described by the complete analysis of the fluorescence temporal point-spread function (TPSF). The behavior of parameters in the fluorescence TPSF is explored, and we demonstrate the method with experimental data from a localized fluorescent inclusion in scattering media to recover images of n, τ, and d. The method has potential application for in vivo fluorescence imaging.

©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Sung-Ho Han, Salman Farshchi-Heydari, and David J. Hall "Analysis of the fluorescence temporal point-spread function in a turbid medium and its application to optical imaging," Journal of Biomedical Optics 13(6), 064038 (1 November 2008). https://doi.org/10.1117/1.3042271

Published: 1 November 2008

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