Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart

Fujian Qu; Crystal M. Ripplinger; Vladimir Nikolski; Cindy Grimm; Igor R. Efimov

doi:10.1117/1.2753748

1 July 2007 Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart

Fujian Qu, Crystal M. Ripplinger, Vladimir Nikolski, Cindy Grimm, Igor R. Efimov

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Journal of Biomedical Optics, Vol. 12, Issue 4, 044019 (July 2007). https://doi.org/10.1117/1.2753748

Abstract

Cardiac fluorescent optical imaging provides the unique opportunity to investigate the dynamics of propagating electrical waves during ventricular arrhythmias and the termination of arrhythmias by strong electric shocks. Panoramic imaging systems using charge-coupled device (CCD) cameras as the photodetector have been developed to overcome the inability to monitor electrical activity from the entire cardiac surface. Photodiode arrays (PDAs) are known to have higher temporal resolution and signal quality, but lower spatial resolution compared to CCD cameras. We construct a panoramic imaging system with three PDAs and image Langendorff perfused rabbit hearts (n=18) during normal sinus rhythm, epicardial pacing, and arrhythmias. The recorded spatiotemporal dynamics of electrical activity is texture mapped onto a reconstructed 3-D geometrical heart model specific to each heart studied. The PDA-based system provides sufficient spatial resolution (1.72 mm without interpolation) for the study of wavefront propagation in the rabbit heart. The reconstructed 3-D electrical activity provides us with a powerful tool to investigate the fundamental mechanisms of arrhythmia maintenance and termination.

©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Fujian Qu, Crystal M. Ripplinger, Vladimir Nikolski, Cindy Grimm, and Igor R. Efimov "Three-dimensional panoramic imaging of cardiac arrhythmias in rabbit heart," Journal of Biomedical Optics 12(4), 044019 (1 July 2007). https://doi.org/10.1117/1.2753748

Published: 1 July 2007

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