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1 July 2007 Vectorial reconstruction of retinal blood flow in three dimensions measured with high resolution resonant Doppler Fourier domain optical coherence tomography
Roland Michaely, Adrian H. Bachmann, Martin L. Villiger, Cedric Blatter, Theo Lasser, Rainer A. Leitgeb
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Journal of Biomedical Optics, Vol. 12, Issue 4, 041213 (July 2007). https://doi.org/10.1117/1.2771553
Abstract
Resonant Doppler Fourier domain optical coherence tomography (FDOCT) is a functional imaging tool for extracting tissue flow. The method is based on the effect of interference fringe blurring in spectrometer-based FDOCT, where the path difference between structure and reference changes during camera integration. If the reference path length is changed in resonance with the Doppler frequency of the sample flow, the signals of resting structures will be suppressed, whereas the signals of blood flow are enhanced. This allows for an easy extraction of vascularization structure. Conventional flow velocity analysis extracts only the axial flow component, which strongly depends on the orientation of the vessel with respect to the incident light. We introduce an algorithm to extract the vessel geometry within the 3-D data volume. The algorithm calculates the angular correction according to the local gradients of the vessel orientations. We apply the algorithm on a measured 3-D resonant Doppler dataset. For validation of the reproducibility, we compare two independently obtained 3-D flow maps of the same volunteer and region.
©(2007) Society of Photo-Optical Instrumentation Engineers (SPIE)
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Roland Michaely, Adrian H. Bachmann, Martin L. Villiger, Cedric Blatter, Theo Lasser, and Rainer A. Leitgeb "Vectorial reconstruction of retinal blood flow in three dimensions measured with high resolution resonant Doppler Fourier domain optical coherence tomography," Journal of Biomedical Optics 12(4), 041213 (1 July 2007). https://doi.org/10.1117/1.2771553
Published: 1 July 2007
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Cited by 61 scholarly publications and 6 patents.
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KEYWORDS
Blood circulation
Doppler tomography
Signal attenuation
Doppler effect
Optical coherence tomography
3D image processing
Cameras
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