Near infrared diffuse reflectance spectroscopy quantification in fatty liver disease

Antoine Uzel; Olivier Lopez; Sophie Chopinet; Michaël Sdika; Bruno Montcel

doi:10.1117/12.3017175

19 June 2024 Near infrared diffuse reflectance spectroscopy quantification in fatty liver disease

Antoine Uzel, Olivier Lopez, Sophie Chopinet, Michaël Sdika, Bruno Montcel

Proceedings Volume PC13010, Tissue Optics and Photonics III; PC1301002 (2024) https://doi.org/10.1117/12.3017175
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Fatty liver disease, or steatosis, is a pathology characterized by the presence of fat droplets in the cytoplasm of hepatocytes. This common and potentially severe condition can result in liver damage and various health complications. The current gold standard method to assess steatosis involves an invasive biopsy and a subjective anatomopathological analysis. In this study, we introduce a novel non-invasive approach based on near infrared diffuse reflectance spectroscopy. Currently, NIR DRS methods are often use to quantify fat fraction but our method provides a way to quantify a fraction of hepatocytes affected by steatosis and thus can be directly compared to anatomopathological analysis. The results obtained from this method demonstrate a strong correlation with the gold standard.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Antoine Uzel, Olivier Lopez, Sophie Chopinet, Michaël Sdika, and Bruno Montcel "Near infrared diffuse reflectance spectroscopy quantification in fatty liver disease", Proc. SPIE PC13010, Tissue Optics and Photonics III, PC1301002 (19 June 2024); https://doi.org/10.1117/12.3017175

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