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19 June 2024 Porphysome nanotechnology: beyond lab, beyond light and beyond cancer
Gang Zheng
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Proceedings Volume PC13009, Clinical Biophotonics III; PC1300908 (2024) https://doi.org/10.1117/12.3024858
Event: SPIE Photonics Europe, 2024, Strasbourg, France
Abstract
Porphysomes are liposome-like nanoparticles self-assembled from a single porphyrin-lipid building block, which enables their inherent multifunction of photothermal, photoacoustic, photodynamic, fluorescence, PET, MRI, and drug delivery. Since its discovery, we have demonstrated porphysome’s high tumor selectivity and multimodal theranostic utilities in diverse tumor models and animal species. We have completed GMP manufacturing, GLP safety studies and clinical trial protocols for its first-in-human use, aka ‘beyond lab’. We have also developed a suite of next generation porphysomes that greatly broadened its theranostic applications from light to sound to radiation. These allow us to pursue new directions of ‘beyond light’ and ‘beyond cancer’.
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Gang Zheng "Porphysome nanotechnology: beyond lab, beyond light and beyond cancer", Proc. SPIE PC13009, Clinical Biophotonics III, PC1300908 (19 June 2024); https://doi.org/10.1117/12.3024858
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KEYWORDS
Cancer
Tumors
Nanotechnology
Ionizing radiation
Photoacoustic spectroscopy
Positron emission tomography
Safety
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