Targeted delivery of femtosecond laser generated reactive oxygen species as a novel therapeutic platform

Sinisa Vukelic

doi:10.1117/12.3009326

13 March 2024 Targeted delivery of femtosecond laser generated reactive oxygen species as a novel therapeutic platform

Sinisa Vukelic

Proceedings Volume PC12875, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XXIV; PC1287505 (2024) https://doi.org/10.1117/12.3009326
Event: SPIE LASE, 2024, San Francisco, California, United States

Abstract

Reactive Oxygen Species (ROS) affect biological processes in many ways, and their effect is a function of strength, content and the exposure duration. Whereas excessive oxidative stress has potential to cause various deleterious events such as damaged protein structure, interfered activation of signaling cascades, and even cell apoptosis, we argue that targeted and carefully dosed application of ROS can be used as a therapeutic modality. In appropriate dosage ROS can induce stimulatory effects on cells and activate pathways leading to migration and collagen synthesis. At the tissue level ROS are utilized in photochemical crosslinking. Thus, we propose use of femtosecond oscillators as a therapeutic platform that can be utilized for ocular wound healing, non-invasive vision correction, as well as treatment of keratoconus and early osteoarthritis.

Conference Presentation

Citation Download Citation

Sinisa Vukelic "Targeted delivery of femtosecond laser generated reactive oxygen species as a novel therapeutic platform", Proc. SPIE PC12875, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XXIV, PC1287505 (13 March 2024); https://doi.org/10.1117/12.3009326

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