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13 March 2024 Glass biochips with tailored volume shapes fabricated by ultrafast laser processing for cancer research
Felix Sima, Kotaro Obata, Mirai Hanzawa, Hiroyuki Kawano, Florin Jipa, Emanuel Axente, Koji Sugioka
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Proceedings Volume PC12872, Laser Applications in Microelectronic and Optoelectronic Manufacturing (LAMOM) XXIX; PC1287207 (2024) https://doi.org/10.1117/12.2692848
Event: SPIE LASE, 2024, San Francisco, California, United States
Abstract
We fabricated hierarchical glass biochips with interior characteristics that can be tailored by adjusting process parameters. By a new derived processing method, termed Femtosecond Laser Assisted chemical Etching Nanoscale Glass Deformation (FLAE-NGD), we have developed graded and hierarchical configurations with dimensions from several hundred micrometers to several hundred nanometers as relevant glass model platforms that mimic cancer cell intravasation-extravasation processes. We were able to control the dimensions of both the widths and lengths of the channels as well as shape and curvatures of interior glass pillars. Various curvatures were successfully prepared for the study of the migration and invasion processes of cancer. We have further evaluated the effect of x-ray exposure on melanoma cells grown in glass biochips and determined the increase of intracellular reactive oxygen species production and cellular DNA breaks with the applied irradiation dose.
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Felix Sima, Kotaro Obata, Mirai Hanzawa, Hiroyuki Kawano, Florin Jipa, Emanuel Axente, and Koji Sugioka "Glass biochips with tailored volume shapes fabricated by ultrafast laser processing for cancer research", Proc. SPIE PC12872, Laser Applications in Microelectronic and Optoelectronic Manufacturing (LAMOM) XXIX, PC1287207 (13 March 2024); https://doi.org/10.1117/12.2692848
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KEYWORDS
Glasses
Cancer
Laser processing
Ultrafast lasers
Miniaturization
Radiotherapy
System integration
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