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Irregularities of ocular pulsatility are associated with some of the most severe eye diseases. Here, we present a high-speed visible light OCT for simultaneous high-resolution structural imaging and measuring local heartbeat-induced micro-displacements in corneas of rodents. The analysis of complex OCT signal dynamics across repeated frame acquisitions enables tissue motion measurements with high spatial and temporal resolution. As a proof of concept, we demonstrate in vivo imaging in corneas of wildtype mice and reveal subtle structural deformations related to ocular pulsation. Our data in mouse eyes hold promise for a passive, noncontact elastography technique that may enable a new paradigm of OCT based measurements and image contrast.
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Lucas May, Sarah Nagl, Antonia Lichtenegger, Conrad Merkle, Andreas Drauschke, Bernhard Baumann, "High-speed visible light optical coherence tomography for high resolution structural and elastographic imaging in the cornea," Proc. SPIE PC12844, Optical Elastography and Tissue Biomechanics XI, PC128440K (18 March 2024); https://doi.org/10.1117/12.3002508