Signal processing of sub-kHz FF-SS-OCT for optoretinography of the human retina

Ewelina Pijewska; Denise Valente; Dae Yu Kim; Maciej M. Bartuzel; Ratheesh K. Meleppat; Reddikumar Maddipatla; Robert J. Zawadzki; Ravi S. Jonnal

doi:10.1117/12.3003095

13 March 2024 Signal processing of sub-kHz FF-SS-OCT for optoretinography of the human retina

Ewelina Pijewska, Denise Valente, Dae Yu Kim, Maciej M. Bartuzel, Ratheesh K. Meleppat, Reddikumar Maddipatla, Robert J. Zawadzki, Ravi S. Jonnal

Author Affiliations +

Proceedings Volume PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII; PC1283010 (2024) https://doi.org/10.1117/12.3003095
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

In this presentation we will evaluate the signal processing steps required to obtain stimulus-evoked nm-scale changes in the photoreceptor outer segment (OS) length using full field swept source optical coherence tomography (FF-SS-OCT). Evaluation of stimulus-evoked OS length changes is the basis of photoreceptor optoretinography (ORG), an emerging test of retinal function. To allow cellular resolution, an adaptive optics (AO) enhanced FF-SS-OCT system was constructed. This system allows up to kHz volume acquisition rates, which greatly reduce retinal motion artifacts. Specifically, the effects of wave number calibration, dispersion compensation, and application of short-time Fourier transform (STFT) on image quality metrics, SNR of individual OCT volumes, and extracted phase noise will be presented.

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Ewelina Pijewska, Denise Valente, Dae Yu Kim, Maciej M. Bartuzel, Ratheesh K. Meleppat, Reddikumar Maddipatla, Robert J. Zawadzki, and Ravi S. Jonnal "Signal processing of sub-kHz FF-SS-OCT for optoretinography of the human retina", Proc. SPIE PC12830, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII, PC1283010 (13 March 2024); https://doi.org/10.1117/12.3003095

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