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13 March 2024 Multimodal elastography to evaluate the in vivo structure-function relationship of lens mechanics in presbyopia
Justin Schumacher, Leana Rohman, Christian Zevallos-Delgado, Marco Ruggeri, Jean-Marie Parel, Fabrice Manns, Kirill Larin, Giuliano Scarcelli
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Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC128240Q (2024) https://doi.org/10.1117/12.3001919
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Presbyopia is a loss of the dynamic accommodation response of our vision and affects everybody as they age. Despite many static corrections available, we still do not address the underlying biomechanical cause of lens stiffness. Novel lens softening therapies are limited by no ability to assess biomechanics in vivo. To address this, we developed a multimodal OCE/Brillouin system that maps spatial-varying modulus of a lens. The lens mechanical signature was measured, and a forward model was used to demonstrate the structure-function relationship of lens stiffness on clinical accommodation. This technique has the potential for patient-specific presbyopia models and therapeutic planning.
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Justin Schumacher, Leana Rohman, Christian Zevallos-Delgado, Marco Ruggeri, Jean-Marie Parel, Fabrice Manns, Kirill Larin, and Giuliano Scarcelli "Multimodal elastography to evaluate the in vivo structure-function relationship of lens mechanics in presbyopia", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC128240Q (13 March 2024); https://doi.org/10.1117/12.3001919
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KEYWORDS
Elastography
In vivo imaging
Mechanics
Data modeling
Eye
Microscopy
Visual process modeling
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