Improved evaluation of retinal hemodynamic response using contrast-enhanced OCTA

PrajaktaB Belekar; Yash Patel; Bernhard Baumann; Conrad Merkle

doi:10.1117/12.3005511

13 March 2024 Improved evaluation of retinal hemodynamic response using contrast-enhanced OCTA

PrajaktaB Belekar, Yash Patel, Bernhard Baumann, Conrad Merkle

Proceedings Volume PC12824, Ophthalmic Technologies XXXIV; PC1282408 (2024) https://doi.org/10.1117/12.3005511
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Retinal vascular impairments, including reduced functional responsiveness, are implicated in a number of prevalent retinal disorders. Improved depth-resolved retinal vasculature imaging is possible using optical coherence tomography angiography (OCTA) after injection of a contrast agent. Flicker stimulated OCTA imaging on C57BL/6 healthy mice was performed to evaluate functional response and vascular connections with and without additional contrast. Major retinal vessels showed an increase in vessel diameter that was more pronounced in a mouse with contrast injection than in one without. Additionally, a contrast-injected mouse showed 6 times more connecting vessels overall. Contrast-enhanced OCTA may improve quantification of hemodynamics in animal models of disease.

Conference Presentation

Citation Download Citation

PrajaktaB Belekar, Yash Patel, Bernhard Baumann, and Conrad Merkle "Improved evaluation of retinal hemodynamic response using contrast-enhanced OCTA", Proc. SPIE PC12824, Ophthalmic Technologies XXXIV, PC1282408 (13 March 2024); https://doi.org/10.1117/12.3005511

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