The rise of antibiotic-resistant infectious diseases is becoming an alarming problem for public health to the difficulty of treatment, resulting in a high number of deaths annually. Photodynamic inactivation (PDI) has shown promise as an effective method, which is based on the use of a photosensitize, when activated by light, generates reactive oxygen species (ROS), causing damage to the metabolic and structures of target cells, resulting in their death. This study aims to analyze the action of curcumin acting as a photosensitizer and the effect on the susceptibility of different antibiotics to Staphylococcus aureus resistant to methicillin (MRSA). The experimental groups and the analyzes were established from the central composite planning (10 µM, 10 J/cm²). The results demonstrated that PDI reduces the concentration of antibiotics needed to act against MRSA compared to the results of the control group. Combining both treatments enhances the action against target cells, enabling successful results.
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