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13 March 2024 Preclinical modeling of perfusion-based fluorescence imaging for the detection of life-threatening necrotizing soft-tissue infections
Samuel S. Streeter, Jason R Gunn, Meaghan T. Hart, Niles P. Donegan, Ambrose Cheung, Kevin S. McIver, Jonathan T. Elliott, Eric R Henderson, Logan M. Bateman
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Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC1282205 (2024) https://doi.org/10.1117/12.2691480
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Necrotizing soft-tissue infections (NSTIs) are aggressive and deadly. A major obstacle to prompt NSTI management is the lack of a definitive diagnostic test, causing treatment delays and increasing mortality. NSTI-affected tissues undergo prominent blood vessel thrombosis invisible to the naked eye that can be rapidly visualized using perfusion-based fluorescence imaging. To validate fluorescence imaging for rapid NSTI detection, we are developing a preclinical mouse model of NSTI using light-producing strains of causative bacteria that have biological equivalence to wild type. Co-registration of our wide-field fluorescence imagery with spectrally distinct, bacterial bioluminescence provides validation of infection presence and spatial extent.
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Samuel S. Streeter, Jason R Gunn, Meaghan T. Hart, Niles P. Donegan, Ambrose Cheung, Kevin S. McIver, Jonathan T. Elliott, Eric R Henderson, and Logan M. Bateman "Preclinical modeling of perfusion-based fluorescence imaging for the detection of life-threatening necrotizing soft-tissue infections", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC1282205 (13 March 2024); https://doi.org/10.1117/12.2691480
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KEYWORDS
Fluorescence imaging
Modeling
Bacteria
Diagnostic tests
Eye
Eye models
In vivo imaging
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