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13 March 2024 Dual modality monitoring of topical formulations within human skin using stimulated Raman scattering (SRS) microscope
Dandan Tu, Nick-Sidney Lemberger, Kristin Wallmeier, Jackson Riseman, Benjamin A. Kuzma, Yuxiao Wei, Ting Chean Khoo, Priyanka Ghosh, Sam G. Raney, Markham C. Luke, Carsten Fallnich, Conor L. Evans
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Proceedings Volume PC12821, Visualizing and Quantifying Drug Distribution in Tissue VIII; PC1282104 (2024) https://doi.org/10.1117/12.3001122
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Stimulated Raman scattering (SRS) microscopy enables label-free and quantitative imaging of active pharmaceutical ingredients within the skin, with superior chemical specificity and spatial and temporal resolution. Here, we present a method to study topical formulations on ex vivo human skin using two modalities, SRS and near-infrared light (NIR) transmission. NIR transmission is used to compensate for the SRS signal variance caused by differences in skin thickness and formulation properties. Optical co-registration of the two modalities enables recording the variance in each pixel. The developed method helps to evaluate the cutaneous pharmacokinetics of tretinoin from tretinoin-containing solution and cream formulations.
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Dandan Tu, Nick-Sidney Lemberger, Kristin Wallmeier, Jackson Riseman, Benjamin A. Kuzma, Yuxiao Wei, Ting Chean Khoo, Priyanka Ghosh, Sam G. Raney, Markham C. Luke, Carsten Fallnich, and Conor L. Evans "Dual modality monitoring of topical formulations within human skin using stimulated Raman scattering (SRS) microscope", Proc. SPIE PC12821, Visualizing and Quantifying Drug Distribution in Tissue VIII, PC1282104 (13 March 2024); https://doi.org/10.1117/12.3001122
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KEYWORDS
Skin
Raman scattering
Microscopes
Near infrared
Light scattering
Signal intensity
Photons
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