PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The development of fluorescent molecular sensors for imaging voltage changes in biological systems has revolutionized neuroscience over the past decade. However, the poor photostability of molecular voltage sensors limits recording times to a few minutes, posing problems for longitudinal studies of network evolution and disease processes. These limitations have led to the uptake of lower-resolution extracellular recording techniques such as multi-electrode arrays (MEAs) for long term neurological research. Here, we present an alternate platform for sensitive high resolution voltage imaging using fluorescent, charge-sensitive defects in a transparent diamond substrate. We demonstrate how this sensing modality can be used to image sub-millivolt signals over millisecond timescales opening new pathways for 2D and 3D neurological imaging applications.
David A. Simpson
"Quantum diamond voltage microscopy for bio-imaging applications", Proc. SPIE PC12657, Quantum Nanophotonic Materials, Devices, and Systems 2023, PC126570C (28 September 2023); https://doi.org/10.1117/12.2682770
ACCESS THE FULL ARTICLE
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
David A. Simpson, "Quantum diamond voltage microscopy for bio-imaging applications," Proc. SPIE PC12657, Quantum Nanophotonic Materials, Devices, and Systems 2023, PC126570C (28 September 2023); https://doi.org/10.1117/12.2682770