Jonathan M. Richardson,1 Tom Y. Cheng,1 Marco Renna,2 George Jordy,1 Matthew S. Stamplis,1 Ana-Maria Mandrilla Vacca,1 Michael Bradshaw,1 Eric Ringdahl,1 Brian F. Aull,1 Megan H. Blackwell,1 Erik K. Duerr,1 Mitchell B. Robinson,2 Stefan A. Carp,2 Maria-Angelica Franceschinihttps://orcid.org/0000-0001-6758-423X2
1MIT Lincoln Lab. (United States) 2Athinoula A. Martinos Ctr. for Biomedical Imaging (United States)
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Functional near-infrared spectroscopy (fNIRS) and diffuse correlation spectroscopy (DCS) have shown promise as non-invasive optical methods for cerebral functional imaging. DCS approaches currently have limited sensitivity in adults. fNIRS sensitivity is also limited, particularly in high-detector-density applications. Sensitivity can be improved using temporal discrimination (TD), where the laser excitation is of short (~400ps) duration and the detector rejects early photons that have not penetrated into the brain while maintain high sensitivity to those that have. We report here on the development of a novel 32x32 Single-Photon Avalanche photo-Detector (SPAD) array and Read-Out Integrated Circuit (ROIC) that can operate in either the visible or NIR enabling high-channel-count TD-fNIRS or TD-DCS systems.
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Jonathan M. Richardson, Tom Y. Cheng, Marco Renna, George Jordy, Matthew S. Stamplis, Ana-Maria Mandrilla Vacca, Michael Bradshaw, Eric Ringdahl, Brian F. Aull, Megan H. Blackwell, Erik K. Duerr, Mitchell B. Robinson, Stefan A. Carp, Maria-Angelica Franceschini, "A 256-channel SPAD detector for time-gated fNIRS and DCS," Proc. SPIE PC12512, Advanced Photon Counting Techniques XVII, PC1251208 (15 June 2023); https://doi.org/10.1117/12.2666270