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The use of a single multimode fiber (MMF) as a high-resolution endoscopic imaging tool is
demonstrated. We show that the scrambled output of a MMF can be used for auto-fluorescence
compressive imaging. By scanning a light spot across the proximal side of the fiber we can create
uncorrelated speckle patterns at the output. Those patterns successively illuminate the biological
sample and for each pattern the integrated intensity is recorded in epi-direction. An image of the brain
tissue was computationally reconstructed using a regularization algorithm. Furthermore, the
presented technique has potential in enhanced acquisition speed and in improving the resolution limit.
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Benjamin Lochocki, Max V. Verweg, Jeroen J. M. Hoozemans, Johannes F. de Boer, Lyubov V. Amitonova, "High-resolution brain imaging via a multimode fiber (Conference Presentation)," Proc. SPIE PC12388, Adaptive Optics and Wavefront Control for Biological Systems IX, PC123880D (16 March 2023); https://doi.org/10.1117/12.2648922