High-fidelity deep functional photoacoustic tomography enhanced by virtual point sources

Yuqi Tang; Shanshan Tang; Chengwu Huang; Paul Klippel; Chenshuo Ma; Nathan Caso; Shigao Chen; Junjie Yao; Yun Jing

doi:10.1117/12.2650850

9 March 2023 High-fidelity deep functional photoacoustic tomography enhanced by virtual point sources

Yuqi Tang, Shanshan Tang, Chengwu Huang, Paul Klippel, Chenshuo Ma, Nathan Caso, Shigao Chen, Junjie Yao, Yun Jing

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC1237912 (2023) https://doi.org/10.1117/12.2650850
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

The most clinically compatible PAT configuration usually employs a linear ultrasound array, which often has a limited detection view and poor image fidelity. Exogenous contrast agents such as nanoparticles can be employed but lacks clinical translation potential. We have developed a new methodology by using clinically-approved microbubble as virtual point sources that strongly scatter the local pressure waves from surround hemoglobin, preserving PAT’s functional capability and clinical translation potential. We can overcome the limited-detection-view problem and achieve high-fidelity functional PAT in deep tissue. We have investigated the working principle and demonstrated proof-of-concept applications using simulations, phantoms, and in vivo small-animal studies.

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Citation Download Citation

Yuqi Tang, Shanshan Tang, Chengwu Huang, Paul Klippel, Chenshuo Ma, Nathan Caso, Shigao Chen, Junjie Yao, and Yun Jing "High-fidelity deep functional photoacoustic tomography enhanced by virtual point sources", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC1237912 (9 March 2023); https://doi.org/10.1117/12.2650850

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KEYWORDS

Acquisition tracking and pointing

Photoacoustic tomography

Hemodynamics

Transducers

Medical research

Nanoparticles

Numerical simulations

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