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17 March 2023 Antimicrobial blue light promotes an important role in enzymatic activity and degradation of β-lactamases.
Carolina dos Anjos, Rox Anderson, Tianhong Dai, Leon Leanse
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Proceedings Volume PC12358, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2023; PC123580B (2023) https://doi.org/10.1117/12.2651168
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
This study investigated the aBL effects on bacterial species carrying β-lactamase genes and alterations in β-lactamase activity following aBL. In addition, we assessed the β-lactamase and protein damage induced by aBL and the bactericidal effect of aBL combined with a β-lactam antibiotic. Our finds demonstrate that aBL can effectively kill strains carrying β-lactamase genes and reduce the β-lactamase activity. We also demonstrated the role of porphyrins on the photoreaction promoted by aBL and the resulting protein damage. Additionally, ceftazidime activity was significantly improved by aBL in a Metallo-β-lactamase strain. Our finds support the aBL against the β-lactamases and encourage future outcomes.
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Carolina dos Anjos, Rox Anderson, Tianhong Dai, and Leon Leanse "Antimicrobial blue light promotes an important role in enzymatic activity and degradation of β-lactamases.", Proc. SPIE PC12358, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2023, PC123580B (17 March 2023); https://doi.org/10.1117/12.2651168
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KEYWORDS
Bacteria
Proteins
Resistance
Microorganisms
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