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2 March 2022 Label-free ultrasensitive detection of a novel ovarian cancer biomarker in mouse samples using microtoroid resonators
Chang Ge, Yisha O. Tang, Gordon Luu, Laura Sanchez, Judith Su
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Proceedings Volume PC11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022; PC1197218 (2022) https://doi.org/10.1117/12.2610571
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Currently there are no biomarkers for ovarian cancer. We discover an ovarian cancer biomarker using mass spectrometry and use microtoroid resonators for label-free ultra-sensitive detection of this marker in ovarian cancer tumor-implanted mice. After characterizing the sensor response with standard solutions, we then perform a quantitative analysis to investigate the concentration of the biomarker in several mouse vaginal lavage samples. The results show that the biomarker levels increase with time, revealing the progression of tumors implanted in mice.
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Chang Ge, Yisha O. Tang, Gordon Luu, Laura Sanchez, and Judith Su "Label-free ultrasensitive detection of a novel ovarian cancer biomarker in mouse samples using microtoroid resonators", Proc. SPIE PC11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022, PC1197218 (2 March 2022); https://doi.org/10.1117/12.2610571
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KEYWORDS
Ovarian cancer
Resonators
Sensors
Tumors
Mass spectrometry
Monoclonal antibodies
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