3D Monte Carlo simulation of light distribution in mouse brain in quantitative photoacoustic tomography

Yuqi Tang; Junjie Yao

doi:10.1117/12.2608780

7 March 2022 3D Monte Carlo simulation of light distribution in mouse brain in quantitative photoacoustic tomography

Yuqi Tang, Junjie Yao

Proceedings Volume PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022; PC1196023 (2022) https://doi.org/10.1117/12.2608780
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Photoacoustic computed tomography (PACT) has great potential in mouse brain imaging. Conventional PACT either assumes homogenous optical fluence or uses simplified attenuation model for optical fluence estimation, resulting in inaccurate estimation of absorption coefficient of the chromophore. To optimize the quantitative performance of PACT, we used MCX 3D Monte Carlo simulation to study the optical fluence distribution in a complete mouse brain model, which contains complete anatomy and blood vasculature information. Our results suggest that optical fluence decays five times globally due to strong scattering tissue and fluctuates locally due to additional optical heterogeneity introduced by blood vessels.

Conference Presentation

Citation Download Citation

Yuqi Tang and Junjie Yao "3D Monte Carlo simulation of light distribution in mouse brain in quantitative photoacoustic tomography", Proc. SPIE PC11960, Photons Plus Ultrasound: Imaging and Sensing 2022, PC1196023 (7 March 2022); https://doi.org/10.1117/12.2608780

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