Ex vivo determination of nerve and surrounding tissue optical properties in rats and human cadavers for nerve-sparing surgical applications

Ezekiel Haugen; Graham A. Throckmorton; Alec B. Walter; Zaiyang Guo; Justin S. Baba; Anita Mahadevan-Jansen

doi:10.1117/12.2608860

9 March 2022 Ex vivo determination of nerve and surrounding tissue optical properties in rats and human cadavers for nerve-sparing surgical applications

Ezekiel Haugen, Graham A. Throckmorton, Alec B. Walter, Zaiyang Guo, Justin S. Baba, Anita Mahadevan-Jansen

Author Affiliations +

Proceedings Volume PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX; PC119490D (2022) https://doi.org/10.1117/12.2608860
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Iatrogenic nerve injuries often occur during surgical procedures yielding high morbidity. Numerous optical techniques are being investigated to provide nerve visualization and monitoring to both avoid and detect nerve injury. However, there is insufficient VIS-IR optical properties data for nerve and surrounding tissues, to facilitate needed advancements in the biophotonic approaches being developed for deployment. To fill this gap, we determined the absorption and reduced scattering coefficients of ex vivo nerve, muscle, tendon, and adipose tissues from four rats and human cadavers between 350-2500nm. The results provide valuable insights for optimizing the optical contrast of nerves for improved surgical guidance.

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Ezekiel Haugen, Graham A. Throckmorton, Alec B. Walter, Zaiyang Guo, Justin S. Baba, and Anita Mahadevan-Jansen "Ex vivo determination of nerve and surrounding tissue optical properties in rats and human cadavers for nerve-sparing surgical applications", Proc. SPIE PC11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX, PC119490D (9 March 2022); https://doi.org/10.1117/12.2608860

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