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Polarization Sensitive Optical Coherence Tomography (PS-OCT) measures the intensity and polarization state of backscattered light to provide information about tissue structure, retardation and depolarization. Developing molecular contrast agents for PS-OCT could also provide physiological, cellular, and molecular information. In this study, we utilize the depolarization and spectral signature of anisotropic gold nanobipyramids (GNBPs) and demonstrate how the optical properties of these nanostructures can be used as contrast agents for PS-OCT in living tissue.
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Pelham Keahey, Peng Si, Martin Villiger, Adam de la Zerda, Brett Bouma, "Living tissue imaging using gold nanobipyramid contrast agents and polarization sensitive optical coherence tomography," Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC1194818 (7 March 2022); https://doi.org/10.1117/12.2612087