Sylvia Desissaire,1 Florian Schwarzhans,1 Stefan Steinerhttps://orcid.org/0000-0002-6183-8224,1 Clemens Vass,1 Georg Fischer,1 Michael Pircher,1 Christoph K. Hitzenberger1
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We introduce a new method, temporal phase contrast (TPC) OCT, to measure sub-micron tissue motion in-vivo in the retina over an extended timeframe, i.e. over several seconds. The analysis is based on the calculation of the phase differences between an initial reference B-scan and each of the subsequent B-scans. In this study, retinal nerve fiber (RNF) tissue deformations induced by retinal vessels pulsating with the heartbeat were investigated in healthy volunteers. We show reproducible results of tissue expansion enabling to quantify the extent of the deformation and access the delay between expansion near the arteries and the veins.
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Sylvia Desissaire, Florian Schwarzhans, Stefan Steiner, Clemens Vass, Georg Fischer, Michael Pircher, Christoph K. Hitzenberger, "Analysis of retinal nerve fiber tissue deformation in-vivo using temporal phase contrast OCT," Proc. SPIE PC11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, PC119480H (7 March 2022); https://doi.org/10.1117/12.2611520