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7 March 2022 Excitatory and inhibitory neuromodulation induced by a single infrared light pulse
Xuedong Zhu, Jen-Wei Lin, Michelle Sander
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Proceedings Volume PC11947, Optogenetics and Optical Manipulation 2022; PC1194705 (2022) https://doi.org/10.1117/12.2607152
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
We found that a single and brief IR light pulse induced a TTX-independent membrane depolarization, whose amplitude depends on the pulse duration and total energy deposition. The depolarization facilitated action potential (AP) generation when the axon was near firing threshold. This depolarization was followed by a membrane hyperpolarization at higher energy levels, which reversed near potassium equilibrium potential and could inhibit AP firing. Pharmacological results indicated that barium-sensitive potassium channels contributed to the hyperpolarization, while further administration of TEA did not change the hyperpolarization. We show that individual and brief IR light pulses can evoke both excitatory and inhibitory effects.
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Xuedong Zhu, Jen-Wei Lin, and Michelle Sander "Excitatory and inhibitory neuromodulation induced by a single infrared light pulse", Proc. SPIE PC11947, Optogenetics and Optical Manipulation 2022, PC1194705 (7 March 2022); https://doi.org/10.1117/12.2607152
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KEYWORDS
Infrared radiation
Axons
Modulation
Potassium
Barium
Fiber amplifiers
Laser sources
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