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7 March 2022 Enhancement of the cutaneous melanin assessment in human skin by in vivo imaging using fast large-area multiphoton exoscope (FLAME)
Juvinch R. Vicente, Griffin R. Lentsch, Amanda Durkin, Mihaela Balu
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Proceedings Volume PC11944, Multiscale Imaging and Spectroscopy III; PC119440J (2022) https://doi.org/10.1117/12.2610037
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
In vivo multiphoton microscopy (MPM) provides non-invasive imaging of living tissues in their native state. Melanin, a fluorophore found in the skin, plays a significant role in various physiological and pathological processes. Quantification of cutaneous melanin provides basis for efficient treatment of pigmentary skin disorders and for differentiating melanoma from benign pigmented lesions. MPM imaging has a potential for non-invasive cutaneous melanin evaluation. We recently reported on the development of a fast large area multiphoton exoscope (FLAME) for in vivo macroscopic imaging with microscopic resolution and enhanced molecular contrast for selective melanin detection. In this work, we demonstrate the benefit of sampling a large volume, using FLAME in vivo, for enhancing the accuracy of the melanin content assessment in human skin.
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Juvinch R. Vicente, Griffin R. Lentsch, Amanda Durkin, and Mihaela Balu "Enhancement of the cutaneous melanin assessment in human skin by in vivo imaging using fast large-area multiphoton exoscope (FLAME)", Proc. SPIE PC11944, Multiscale Imaging and Spectroscopy III, PC119440J (7 March 2022); https://doi.org/10.1117/12.2610037
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KEYWORDS
Skin
In vivo imaging
Luminescence
Image resolution
Melanoma
Multiphoton microscopy
Resolution enhancement technologies
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