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Laser speckle contrast imaging (LSCI) illuminates continuous-wave (CW) laser light on tissue surface. We assembled an integrated LSCI system combining a CW laser at 785 nm and a picosecond pulsed laser at 775 nm. A CMOS camera collected images from mouse head with intact skull. The pulsed laser with engineered diffuser captured more details of brain vessels compared to the CW laser with glass diffusers. The consecutive ligations of left and right common carotid arteries resulted in significant CBF reductions. This research lays the ground to develop multimodal imaging systems integrating LSCI and other imaging techniques with shared pulse illuminations.
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