CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 9725 > Article
Presentation
27 April 2016 Plasmonic paper: an emerging analytical platform for highly sensitive biosensors (Conference Presentation)
Srikanth Singamaneni
Author Affiliations +
Proceedings Volume 9725, Frontiers in Biological Detection: From Nanosensors to Systems VIII; 97250E (2016) https://doi.org/10.1117/12.2215013
Event: SPIE BiOS, 2016, San Francisco, California, United States
Abstract
Plasmonic biosensors hold enormous potential for the development of low-cost, label-free, point-of-care biodiagnostics. However, two major challenges need to be overcome to reap the benefits of this class of biosensors: (i) state-of-the-art plasmonic biosensors either offer limited sensitivity or are impractical for real-world applications due to their poor stability and excessive cost; (ii) these biosensors rely on natural antibodies, which are high-cost and impose severe limitations in handling, storage and device integration. We demonstrate that a common filter paper can be transformed into a plasmonic sensing platform for highly sensitive and selective detection of trace levels of chemical and biological analytes. We also demonstrate that short peptides as biorecognition elements compared to larger antibodies as target capture agents offer several advantages. Using a bioplasmonic paper device, we demonstrate the selective and sensitive detection of the cardiac biomarker troponin I. The smaller sized peptide provides higher sensitivity and a lower detection limit using a bioplasmonic paper device. Furthermore, the excellent shelf-life and thermal stability of peptide-based plasmonic biosensors, which precludes the need for special storage conditions, makes it ideal for use in resource-limited settings. We also demonstrate plasmonic biosensors based on artificial antibodies by molecularly imprinting the plasmonic nanotransducers. Apart from significantly lowering the cost, these developments are critical for translating plasmonic sensors to point-of-care and resource-limited settings.
Conference Presentation
© (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Srikanth Singamaneni "Plasmonic paper: an emerging analytical platform for highly sensitive biosensors (Conference Presentation)", Proc. SPIE 9725, Frontiers in Biological Detection: From Nanosensors to Systems VIII, 97250E (27 April 2016); https://doi.org/10.1117/12.2215013
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Biosensors
Plasmonics
Biological research
Point-of-care devices
Biological and chemical sensing
Biological detection systems
Biosensing
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top