High-sensitivity high-throughput chip based biosensor array for multiplexed detection of heavy metals

Hai Yan; Naimei Tang; Grace A. Jairo; Swapnajit Chakravarty; Diane A. Blake; Ray T. Chen

doi:10.1117/12.2212731

22 April 2016 High-sensitivity high-throughput chip based biosensor array for multiplexed detection of heavy metals

Hai Yan, Naimei Tang, Grace A. Jairo, Swapnajit Chakravarty, Diane A. Blake, Ray T. Chen

Proceedings Volume 9725, Frontiers in Biological Detection: From Nanosensors to Systems VIII; 972507 (2016) https://doi.org/10.1117/12.2212731
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Heavy metal ions released into the environment from industrial processes lead to various health hazards. We propose an on-chip label-free detection approach that allows high-sensitivity and high-throughput detection of heavy metals. The sensing device consists of 2-dimensional photonic crystal microcavities that are combined by multimode interferometer to form a sensor array. We experimentally demonstrate the detection of cadmium-chelate conjugate with concentration as low as 5 parts-per-billion (ppb).

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Citation Download Citation

Hai Yan, Naimei Tang, Grace A. Jairo, Swapnajit Chakravarty, Diane A. Blake, and Ray T. Chen "High-sensitivity high-throughput chip based biosensor array for multiplexed detection of heavy metals", Proc. SPIE 9725, Frontiers in Biological Detection: From Nanosensors to Systems VIII, 972507 (22 April 2016); https://doi.org/10.1117/12.2212731

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