Imaging pulse wave velocity in mouse retina using swept-source OCT
(Conference Presentation)

Shaozhen Song; Wei Wei; Ruikang K. Wang

doi:10.1117/12.2214678

26 April 2016 Imaging pulse wave velocity in mouse retina using swept-source OCT (Conference Presentation)

Shaozhen Song, Wei Wei, Ruikang K. Wang

Proceedings Volume 9707, Dynamics and Fluctuations in Biomedical Photonics XIII; 97070O (2016) https://doi.org/10.1117/12.2214678
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Blood vessel dynamics has been a significant subject in cardiology and internal medicine, and pulse wave velocity (PWV) on artery vessels is a classic evaluation of arterial distensibility, and has never been ascertained as a cardiovascular risk marker. The aim of this study is to develop a high speed imaging technique to capture the pulsatile motion on mouse retina arteries with the ability to quantify PWV on any arterial vessels. We demonstrate a new non-invasive method to assess the vessel dynamics on mouse retina. A Swept-source optical coherence tomography (SS-OCT) system is used for imaging micro-scale blood vessel motion. The phase-stabilized SS-OCT provides a typical displacement sensitivity of 20 nm. The frame rate of imaging is ~16 kHz, at A-line rate of ~1.62 MHz, which allows the detection of transient pulse waves with adequate temporal resolution. Imaging volumes with repeated B-scans are obtained on mouse retina capillary bed, and the mouse oxymeter signal is recorded simultaneously. The pulse wave on artery and vein are resolved, and with the synchronized heart beat signal, the temporal delay on different vessel locations is determined. The vessel specific measurement of PWV is achieved for the first time with SS-OCT, for pulse waves propagating more than 100 cm/s. Using the novel methodology of retinal PWV assessment, it is hoped that the clinical OCT scans can provide extended diagnostic information of cardiology functionalities.

Conference Presentation

Citation Download Citation

Shaozhen Song, Wei Wei, and Ruikang K. Wang "Imaging pulse wave velocity in mouse retina using swept-source OCT (Conference Presentation)", Proc. SPIE 9707, Dynamics and Fluctuations in Biomedical Photonics XIII, 97070O (26 April 2016); https://doi.org/10.1117/12.2214678

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available