Optogenetic stimulation of myelination
(Conference Presentation)

In Hong Yang; Hae Ung Lee; Nitish V. Thakor

doi:10.1117/12.2212607

26 April 2016 Optogenetic stimulation of myelination (Conference Presentation)

In Hong Yang, Hae Ung Lee, Nitish V. Thakor

Proceedings Volume 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation; 96902A (2016) https://doi.org/10.1117/12.2212607
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Myelination is governed by axon-glia interaction which is modulated by neural activity. Currently, the effects of subcellular activation of neurons which induce neural activity upon myelination are not well understood. To identify if subcellular neuronal stimulation can enhance myelination, we developed a novel system for focal stimulation of neural activity with optogenetic in a compartmentalized microfluidic platform. In our systems, stimulation for neurons in restricted subcellular parts, such as cell bodies and axons promoted oligodendrocyte differentiation and the myelination of axons the just as much as whole cell activation of neurons did. The number of premature O4 positive oligodendrocytes was reduced and the numbers of mature and myelin basic protein-positive oligodendrocytes was increased both by subcellular optogenetic stimulation.

Conference Presentation

Citation Download Citation

In Hong Yang, Hae Ung Lee, and Nitish V. Thakor "Optogenetic stimulation of myelination (Conference Presentation)", Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96902A (26 April 2016); https://doi.org/10.1117/12.2212607

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KEYWORDS

Optogenetics

Neurons

Axons

Microfluidics

Modulation

Current controlled current source

Neurophotonics

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