Fiber-based tissue identification for electrode placement in deep brain stimulation neurosurgery
(Conference Presentation)

Damon T. DePaoli; Nicolas Lapointe; Laurent Goetz; Martin Parent; Michel Prudhomme M.D.; Léo Cantin M.D.; Tigran Galstian; Younès Messaddeq; Daniel C. Côté

doi:10.1117/12.2213353

26 April 2016 Fiber-based tissue identification for electrode placement in deep brain stimulation neurosurgery (Conference Presentation)

Damon T. DePaoli, Nicolas Lapointe, Laurent Goetz, Martin Parent, Michel Prudhomme M.D., Léo Cantin M.D., Tigran Galstian, Younès Messaddeq, Daniel C. Côté

Author Affiliations +

Proceedings Volume 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation; 96900G (2016) https://doi.org/10.1117/12.2213353
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Deep brain stimulation’s effectiveness relies on the ability of the stimulating electrode to be properly placed within a specific target area of the brain. Optical guidance techniques that can increase the accuracy of the procedure, without causing any additional harm, are therefore of great interest. We have designed a cheap optical fiber-based device that is small enough to be placed within commercially available DBS stimulating electrodes’ hollow cores and that is capable of sensing biological information from the surrounding tissue, using low power white light. With this probe we have shown the ability to distinguish white and grey matter as well as blood vessels, in vitro, in human brain samples and in vivo, in rats. We have also repeated the in vitro procedure with the probe inserted in a DBS stimulating electrode and found the results were in good agreement. We are currently validating a second fiber optic device, with micro-optical components, that will result in label free, molecular level sensing capabilities, using CARS spectroscopy. The final objective will be to use this data in real time, during deep brain stimulation neurosurgery, to increase the safety and accuracy of the procedure.

Conference Presentation

Citation Download Citation

Damon T. DePaoli, Nicolas Lapointe, Laurent Goetz, Martin Parent, Michel Prudhomme M.D., Léo Cantin M.D., Tigran Galstian, Younès Messaddeq, and Daniel C. Côté "Fiber-based tissue identification for electrode placement in deep brain stimulation neurosurgery (Conference Presentation)", Proc. SPIE 9690, Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation, 96900G (26 April 2016); https://doi.org/10.1117/12.2213353

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
PRESENTATION

WATCH
PRESENTATION SAVE TO MY LIBRARY

GET CITATION

KEYWORDS

Electrodes

Brain stimulation

Brain

In vitro testing

Tissues

Biosensing

Blood vessels

Show All Keywords

Keywords/Phrases

Search In:

Publication Years