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The papers included in this volume were part of the technical conference cited on the cover and title page. Papers were selected and subject to review by the editors and conference program committee. Some conference presentations may not be available for publication. The papers published in these proceedings reflect the work and thoughts of the authors and are published herein as submitted. The publisher is not responsible for the validity of the information or for any outcomes resulting from reliance thereon. Please use the following format to cite material from this book: Author(s), “Title of Paper,” in Clinical and Biomedical Spectroscopy and Imaging IV, edited by J. Quincy Brown, Volker Deckert, Proc. of SPIE-OSA Biomedical Optics Vol. 9537 (SPIE, Bellingham, WA, 2015) Article CID Number. ISSN: 1605-7422 ISBN: 9781628417029 Copublished by SPIE P.O. Box 10, Bellingham, Washington 98227-0010 USA Telephone +1 360 676 3290 (Pacific Time) · Fax +1 360 647 1445 and The Optical Society 2010 Massachusetts Ave., N.W., Washington, D.C., 20036 USA Telephone 1 202/223-8130 (Eastern Time)· Fax 1 202/223-1096 Copyright © 2015, Society of Photo-Optical Instrumentation Engineers and The Optical Society. Copying of material in this book for internal or personal use, or for the internal or personal use of specific clients, beyond the fair use provisions granted by the U.S. Copyright Law is authorized by SPIE subject to payment of copying fees. The Transactional Reporting Service base fee for this volume is $18.00 per article (or portion thereof), which should be paid directly to the Copyright Clearance Center (CCC), 222 Rosewood Drive, Danvers, MA 01923. Payment may also be made electronically through CCC Online at copyright.com. Other copying for republication, resale, advertising or promotion, or any form of systematic or multiple reproduction of any material in this book is prohibited except with permission in writing from the publisher. The CCC fee code is 1605-7422/15/$18.00. Printed in the United States of America. Publication of record for individual papers is online in the SPIE Digital Library.
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AuthorsNumbers in the index correspond to the last two digits of the six-digit citation identifier (CID) article numbering system used in Proceedings of SPIE. The first four digits reflect the volume number. Base 36 numbering is employed for the last two digits and indicates the order of articles within the volume. Numbers start with 00, 01, 02, 03, 04, 05, 06, 07, 08, 09, 0A, 0B…0Z, followed by 10-1Z, 20-2Z, etc. Abdat, F., 0F Abeygunawardhana, Pradeep K. W., 14, 15 Amouroux, M., 0F Anand, Suresh, 0I, 1R Arifler, Dizem, 0M Artemyev, D. N., 2H Artyushenko, V., 20 Arya, Shobhit, 17 Atkins, Chad G., 0X Awazu, Kunio, 1C Babar, H., 1T Baranov, Alexander V., 2C, 2E Baria, Enrico, 1R Bashkatov, A. N., 1P Baskaran, M., 28 Batista, Ana, 09 Belousov, Vsevolod, 10 Berlien, H.-P., 20 Bernatova, Silvie, 03 Beuf, Olivier, 0L Bjorgan, Asgeir, 0C, 12 Blades, Michael W., 0X Blondel, W., 0F Bogomolov, A., 20 Borovkova, M. A., 2A Braglia, A., 0S Brandstetter, M., 13 Braschi, G., 0S Bratchenko, I. A., 2H Brittenham, G. M., 06 Brown, J. Quincy, 0A, 0K, 0P Bruns, Thomas, 16 Buccoliero, Anna Maria, 0I Bucharskaya, A. B., 1P Buckley, Kevin, 0X Bürmen, Miran, 0R Bykov, A. V., 24 Canaple, Laurence, 0L Castejón, Olga Ciutad, 09 Ceja-Fdez, Andrea, 1H Cepeda-Pérez, E. I., 1H Chen, Chi, 1O Chen, Deborah, 0X Chidangil, Santhosh, 0J Chiew, Geraldine Giap Ying, 1B Chuang, Min-Jie, 1Q Cicchi, Riccardo, 0I, 1R Cigada, A., 0S Clancy, Neil T., 17 Cosci, Alessandro, 1R Crisci, Alfonso, 0I De Giorgi, Vincenzo, 0I, 1R de la Rosa, E., 1H Devine, Dana V., 0X Dinten, Jean-Marc, 0E Dolotov, L. E., 1P Domingues, José Paulo, 09 Dorez, Hugo, 0L Douplik, A., 1T Druzhkova, Irina, 10 Du, Xiaofei, 17 Dudenkova, Varvara, 10 Duliu, Alexandru, 22 Duraibabu, D. B., 0S Eichler, H., 20 Elfer, Katherine N., 0A, 0K, 0P Elson, Daniel S., 17 Fedorov, Anatoly V., 2C, 2E Fujiwara, Masaru, 14 Gaillard, Sophie, 0L Gallati, M., 0S Gardiazabal, José, 22 Genin, V. D., 1P Genina, E. A., 1P Giordano, Flavio, 0I Gnyba, M., 0Z, 1N Gonzalez-Yebra, Ana Lilia, 1H Gorin, D. A., 1P Goryacheva, I. Yu., 1P Graefe, Susanna, 05 Graf, A., 1J Grafen, M., 13 Guermeur, Y., 0F Guerrini, Renzo, 0I Guillaud, Martial, 0M Gusev, S. I., 2A Hanna, George B., 17 Haronikova, Andrea, 03 Heise, H. M., 13 Hennig, G., 06 Hessling, M., 1J, 2B Hidalgo, Alberto, 1H Homann, C., 06 Hosono, Satsuki, 15 Hsiao, Yi-Hsien, 1Q Hsieh, Hong-Po, 1Q Hsu, Fang-Wei, 1Q Ihrig, D., 13 Imbaud, Pierre, 26 Inohara, Daichi, 15 Ishida, Akane, 15 Ishii, Katsunori, 1C Ishimaru, Ichiro, 14, 15 Jędrzejewska-Szczerska, M., 0Z, 1N Jeong, Hieyong, 2I Jesmond, Hong Xun Jie, 28 Jezek, Jan, 03 Jo, Na rae, 1F John, Pauline, 11 Josse, Gwendal, 0E K., Unnikrishnan V., 0J Kakino, Satoko, 1E Kannadorai, Ravi Kumar, 1B Kapsokalyvas, Dimitrios, 1R Karpienko, K., 1N Kartha, V. B., 0J Khodzitsky, M. K., 2A Khristoforova, Y. A., 2H Kido, Michiko, 2I Kienle, Alwin, 18 Kimbrell, Hillary Z., 0A, 0P Kochubey, V. I., 1P, 24 Koenig, Anne, 0E Konyukhova, J. G., 1P, 24 Kozintseva, M. D., 1P Kozlov, S. V., 2H Krause, H., 20 Kuehn, A., 1J Kuznetsova, Vera, 2E Lacey, Michelle, 0P Lang, A., 06 Larsson, Marcus, 0C Lasser, Tobias, 22 Laun, T., 2B Le Digabel, Jimmy, 0E Lee, Benjamin R., 0P Lee, Ki joong, 1F Leen, G., 0S Lendl, B., 13 Leonhardt, S., 13 Leroux, Denis F., 26 Lewis, E., 0S Li, An, 1O Likar, Boštjan, 0R Lilge, L., 1T Liu, Quan, 1B Liu, Y., 0S Lomova, M., 1P López-Luke, T., 1H Loschenov, Victor, 05 Lukina, Maria, 10 Lukyanov, Sergey, 10 Luo, Kathy Qian, 1B Macchi, E. G., 0S Maio, Vincenza, 0I, 1R Mandava, Sree, 0P Manoj, Murali, 11 Mantz, H., 1J Martynenko, Irina V., 2C, 2E Maslov, Vladimir G., 2C, 2E Massi, Daniela, 0I, 1R Matsui, Daichi, 1C Matsuura, Yuji, 1E Midahuen, Rony, 26 Milanic, Matija, 0C Milewska, D., 1N Miller, Christopher, 0K Miller, R., 1J Minet, O., 20 Mlynarikova, Katarina, 03 Morgado, Miguel, 09 Moryatov, A. A., 2H Moser, H., 13 Moussata, Driffa, 0L Muenzer, M., 2B Müller, Dennis, 18 Murukeshan, V. M., 28 Myakinin, O. O., 2H Myllylä, T. S., 0Z Nacy, L., 1T Naglič, Peter, 0R Nalpantidis, K., 13 Navab, Nassir, 22 Navolokin, N. A., 1P Nesi, Gabriella, 0I Nishiyama, Akira, 14, 15 Nogo, Kosuke, 15 Nothelfer, Steffen, 18 Obruca, Stanislav, 03 Ohno, Yuko, 2I Ongole, Ravikiran, 0J Orlova, Anna O., 2C, 2E Ostendorf, A., 13 Pai, Keerthilatha M., 0J Pandya, A., 1T Patil, Ajeetkumar, 0J Pavone, Francesco Saverio, 0I, 1R Pérez-Mayen, L., 1H Pernuš, Franjo, 0R Perrin, Guillaume, 26 Perrone, G., 0S Pescatore, Jeremie, 26 Pieszczek, Ł., 20 Pimpinelli, Nicola, 0I, 1R Poeggel, S., 0S Popov, A. P., 1P, 24 Princz, S., 1J, 2B Quadrado, Maria João, 09 Randeberg, Lise Lyngsnes, 0C, 12 Rao, Suresh R., 11 Richter, Verena, 16 Roig, Blandine, 0E Rossari, Susanna, 0I, 1R Ryabova, Anastasia, 05 Sablong, Raphaël, 0L Saeb Gilani, T., 20 Saiko, G., 1T Saint-Jalmes, Hervé, 0L Samek, Ota, 03 Sasazawa, Shuhei, 1E Sato, Shun, 14, 15 Scalfi-Happ, Claudia, 05 Schelkanova, I., 1T Schickinger, Sarah, 16 Schlichenmeyer, Tyler C., 0P Schneckenburger, Herbert, 16 Schulte, F., 20 Schulze, H. Georg, 0X Sergeeva, Tatiyana, 10 Shah, D., 1T Shen, Junfei, 1O Shin, Yong-Beom, 1F Shinoj, V. K., 28 Shirmanova, Marina, 10 Sholl, Andrew B., 0A, 0K, 0P Siler, Martin, 03 Silva, Susana F., 09 Skaptsov, A. A., 24 Speranskaya, E., 1P Stark, Julian, 18 Steiner, Rudolf, 05 Stepp, H., 06 Stoyanov, Danail, 17 Strepitov, M. A., 2A Strömberg, Tomas, 0C Sujatha, N., 11 Sukhorukov, G. B., 1P Sung, Kung-Bin, 1Q Suzuki, Satoru, 14, 15 Suzuki, Yo, 15 Terentyuk, G. S., 1P Tien, Gen-Hao, 1Q Tin, Aung, 28 Torres-Castro, Alejandro, 1H Tosi, D., 0S Tuchin, V. V., 1P, 24 Tulman, David B., 0A, 0P Turner, Robin F. B., 0X Urniaż, R., 0Z Usenov, I., 20 Vahlsing, T., 13 Vallan, A., 0S Vasa, Nilesh J., 11 Visheratina, Anastasia K., 2C, 2E Vivero-Escoto, Juan, 1H Vogeser, M., 06 Volkova, E. K., 1P, 24 Wada, Kenji, 14, 15 Wagner, Michael, 16 Wang, Huihui, 1O Wang, Mei, 0A, 0P Weber, Petra, 16 Wenzel, U., 1J, 2B Wittig, Rainer, 05 Wróbel, M. S., 0Z, 1N Wu, Yisi, 1O Yamada, Kenji, 2I Yanina, I. Yu., 1P, 24 Yokoyama, Moe, 2I Zabarylo, U., 20 Zagaynova, Elena, 10 Zakharov, V. P., 2H Zemanek, Pavel, 03 Zheng, Zhenrong, 1O Conference CommitteeGeneral Chairs
Programme Chairs
Conference Chairs
Conference Programme Committee
Session Chairs
IntroductionThese proceedings are from Clinical and Biomedical Spectroscopy and Imaging IV, held June 22-24, 2015 at the European Conferences on Biomedical Optics in Munich, Germany. This year’s conference comprised 45 oral and 42 poster presentations from leading international research groups. The conference was organized into five tracks and ten sessions including: Biospectroscopy and POC Diagnostics; Clinical and Preclinical Diagnostics I and II; Clinical and Preclinical Tissue Characterization I and II; Minimally Invasive Diagnostics / Laboratory Medicine I and II; and Novel Techniques in Diagnosis, Therapy, and Monitoring. A poster session and corresponding poster preview session were also held. The Biospectroscopy and POC Diagnostics session contained six oral presentations, on topics ranging from label-free Raman analysis of microorganisms to fluorescence-based rapid porphyria diagnostic tests and multi-spectral surface plasmon resonance sensing. The Clinical and Preclinical Diagnostics track covered two sessions containing 10 oral presentations. Reports included a number of ex vivo and in vivo clinical applications, including the use of targeted fluorescence guidance in gastrointestinal endoscopy, fluorescence lifetime imaging of corneal metabolism, rapid near-patient fluorescence microscopy of prostate biopsies, tracking of lipids and invasomes in stratum corneum using TERS, noninvasive detection of hypercholesterolemia using hyperspectral skin imaging, comprehensive analysis of in vivo skin optical properties and vascular parameters using diffuse reflectance spectroscopy, deep skin optical property extraction using diffuse reflectance spectroscopy, improved precancer diagnosis using fusion of autofluorescence and diffuse reflectance spectroscopy, the use of diffuse optics to probe the bone marrow for oncological management, and characterization of the thyroid using diffuse optics. The Clinical and Preclinical Tissue Characterization track also covered two sessions with 11 oral presentations, and included reports on tissue diagnostics using a combined Raman and fluorescence fiber probe, early diagnosis of tongue malignancies using fluorescence spectroscopy, a fluorescent replacement for traditional H&E histopathology, characterization of colitis using autofluorescence spectroscopy, analysis of length-scale variations on light scattering patterns of cells, the use of NIRS to monitor tumor microwave ablation, clinical results on the use of Raman spectroscopy to discriminate inflammatory bowel diseases, the use of structured illumination microscopy to image entire prostate surgical margins, an analysis of the effect of realistic fiber probe interfaces on Monte-Carlo simulated diffuse reflectance, fiber optic thermotherapy for liver tumors, and the effects of pressure on tissue optical properties measured by single-fiber reflectance spectroscopy. The Minimally Invasive Diagnostics/Laboratory Medicine track covered two sessions with 12 oral presentations. Topics included lab-on-a-chip SERS for levofloxacin detection in body fluid, SERS for detection of harmful environmental substances, Raman spectroscopy of biogenic gases in hollow-core fibers, Raman spectroscopic temporal monitoring of the quality of stored whole donated blood, a novel method to create a universal calibration data set for Raman reconstruction based on Wiener estimation, detection of propofol in blood by Raman spectroscopy, intracellular pH sensing in cells using genetically encoded ratiometric sensors, measurement of aqueous glucose using differential absorption frequency domain OCT, real time medical diagnostics using hyperspectral imaging, spectroscopic characterization of an ultra-broadband tunable quantum cascade laser, spectroscopic imaging of blood glucose in superficial skin vessels, and a battery operated ATR Fourier spectrometer for in situ glucose monitoring. The Novel Techniques in Diagnosis, Therapy, and Monitoring contained six oral presentations on 3D imaging of apoptosis using light sheet microscopy, reflectance property analysis of RF-fused bowel tissues, analysis of yeast cells using light scattering microscopy, the use of light scattering microscopy for probing apoptosis and tumor cell recognition, the use of 5-ALA for see-and-treat in Barrett’s esophagus cellular models, and the use of gold nanorods to track cell death during plasmonic photothermal therapy. The conference chairs very gratefully acknowledge the members of the programme committee for their work in peer reviewing and scoring the three-page summaries submitted to the conference. In addition, we are grateful to SPIE staff for their help and support during the organization of the conference. Finally, we would like to thank all of the conference attendees and authors for contributing to this year’s successful conference. J. Quincy Brown Volker Deckert |
