Effects of ICG concentration on the optical properties of erythrocyte-derived nano-vectors

Jack Tang; Baharak Bahmani; Joshua Burns; Vicente Nuñez; Jenny Mac; Danielle Bacon; Valentine Vullev; Victor Sun; Wangcun Jia; J. S. Nelson M.D.; Bahman Anvari

doi:10.1117/12.2079796

11 March 2015 Effects of ICG concentration on the optical properties of erythrocyte-derived nano-vectors

Jack Tang, Baharak Bahmani, Joshua Burns, Vicente Nuñez, Jenny Mac, Danielle Bacon, Valentine Vullev, Victor Sun, Wangcun Jia, J. S. Nelson M.D., Bahman Anvari

Author Affiliations +

Proceedings Volume 9341, Bioinspired, Biointegrated, Bioengineered Photonic Devices III; 93410H (2015) https://doi.org/10.1117/12.2079796
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Erythrocyte-based nanoparticle platforms can offer long circulation times not offered by traditional drug delivery methods. We have developed a novel erythrocyte-based nanoparticle doped with indocyanine green (ICG), the only FDA-approved near-infrared chromophore. Here, we report on the absorption and fluorescence emission characteristics of these nanoparticles fabricated using ICG concentrations in the range of 161-323 μM. These nanoparticles may serve as biocompatible optical materials for various clinical imaging and phototherapeutic applications.

Citation Download Citation

Jack Tang, Baharak Bahmani, Joshua Burns, Vicente Nuñez, Jenny Mac, Danielle Bacon, Valentine Vullev, Victor Sun, Wangcun Jia, J. S. Nelson M.D., and Bahman Anvari "Effects of ICG concentration on the optical properties of erythrocyte-derived nano-vectors", Proc. SPIE 9341, Bioinspired, Biointegrated, Bioengineered Photonic Devices III, 93410H (11 March 2015); https://doi.org/10.1117/12.2079796

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