Common-path diffraction optical tomography  with a low-coherence illumination for reducing speckle noise

Seungwoo Shin; Youngchan Kim; KyeoReh Lee; Kyoohyun Kim; Young-Jin Kim; HyunJoo Park; YongKeun Park

doi:10.1117/12.2175845

11 March 2015 Common-path diffraction optical tomography with a low-coherence illumination for reducing speckle noise

Seungwoo Shin, Youngchan Kim, KyeoReh Lee, Kyoohyun Kim, Young-Jin Kim, HyunJoo Park, YongKeun Park

Proceedings Volume 9336, Quantitative Phase Imaging; 933629 (2015) https://doi.org/10.1117/12.2175845
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Common-path diffraction optical tomography (cDOT) is a non-invasive and label-free optical holographic technique for measuring both the three-dimensional refractive index (RI) tomograms and two-dimensional dynamic phase images of a sample. Due to common-path geometry, cDOT provides quantitative phase imaging with high phase sensitivity. However, the image quality of the cDOT suffers from speckle noise; the use of a monochromatic laser inevitably results in the formation of parasitic fringe patterns in measured quantitative phase images. Here, we present a technique to reduce speckle noise in the cDOT using a low-coherence illumination source. Utilizing a Ti-sapphire pulsed laser in the cDOT, we achieved the reduction of speckle noise in both the three-dimensional RI tomograms and two-dimensional dynamic phase images.

Citation Download Citation

Seungwoo Shin, Youngchan Kim, KyeoReh Lee, Kyoohyun Kim, Young-Jin Kim, HyunJoo Park, and YongKeun Park "Common-path diffraction optical tomography with a low-coherence illumination for reducing speckle noise", Proc. SPIE 9336, Quantitative Phase Imaging, 933629 (11 March 2015); https://doi.org/10.1117/12.2175845

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