Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS)

Jana M. Kainerstorfer; Angelo Sassaroli; Kristen T. Tgavalekos; Sergio Fantini

doi:10.1117/12.2077816

12 March 2015 Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS)

Jana M. Kainerstorfer, Angelo Sassaroli, Kristen T. Tgavalekos, Sergio Fantini

Proceedings Volume 9319, Optical Tomography and Spectroscopy of Tissue XI; 93190N (2015) https://doi.org/10.1117/12.2077816
Event: SPIE BiOS, 2015, San Francisco, California, United States

Abstract

Coherent Hemodynamics Spectroscopy (CHS) is a novel technique for non-invasive measurements of local microcirculation quantities such as the capillary blood transit times and dynamic autoregulation. The basis of CHS is to measure, for instance with near-infrared spectroscopy (NIRS), peripheral coherent hemodynamic changes that are induced by controlled perturbations in the systemic mean arterial pressure (MAP). In this study, the MAP perturbation was induced by the fast release of two pneumatic cuffs placed around the subject’s thighs after they were kept inflated (at 200 mmHg) for two minutes. The resulting transient changes in cerebral oxy- (O) and deoxy- (D) hemoglobin concentrations measured with NIRS on the prefrontal cortex are then described by a novel hemodynamic model, from which quantifiable parameters such as the capillary blood transit time and a cutoff frequency for cerebral autoregulation are obtained. We present results on eleven healthy volunteers in a protocol involving measurements during normal breathing and during hyperventilation, which is known to cause a hypocapnia-induced increase in cerebral autoregulation. The measured capillary transit time was unaffected by hyperventilation (normal breathing: 1.1±0.1 s; hyperventilation: 1.1±0.1 s), whereas the cutoff frequency of autoregulation, which increases for higher autoregulation efficiency, was indeed found to be significantly greater during hyperventilation (normal breathing: 0.017±0.002 Hz; hyperventilation: 0.034±0.005 Hz). These results provide a validation of local cerebral autoregulation measurements with the new technique of CHS.

Citation Download Citation

Jana M. Kainerstorfer, Angelo Sassaroli, Kristen T. Tgavalekos, and Sergio Fantini "Dynamic cerebral autoregulation measured with coherent hemodynamics spectroscopy (CHS)", Proc. SPIE 9319, Optical Tomography and Spectroscopy of Tissue XI, 93190N (12 March 2015); https://doi.org/10.1117/12.2077816

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KEYWORDS

Capillaries

Hemodynamics

Blood

Near infrared spectroscopy

Spectroscopy

Autoregressive models

Linear filtering

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